Evidence map›Paper›PMID 39262774›Full record

ArticleiScience2024

Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness.

William D Leineweber, Maya Z Rowell, Sural K Ranamukhaarachchi, Alyssa Walker, Yajuan Li, Jorge Villazon, Aida Mestre-Farrera, Zhimin Hu, Jing Yang, Lingyan Shi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Imaging Cellular Metabolic Rewiring with SuMMIT-SRS.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Iron and Cancer.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

William D LeineweberDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Maya Z RowellDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Sural K RanamukhaarachchiDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Alyssa WalkerDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Yajuan LiDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Jorge VillazonDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Aida Mestre-FarreraDepartment of Pharmacology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Zhimin HuDepartment of Pharmacology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Jing YangDepartment of Pharmacology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Lingyan ShiDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Stephanie I FraleyDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

Funding

HIPC Data Coordinating CenterU01AI167892 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Steven H. Kleinstein, Bjoern Peters · 2022 to 2026
$18.7M
The Cancer Cell Map Initiative v2.0U54CA274502 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Trey Ideker, Nevan J Krogan · 2022 to 2026
$14.2M
UCSD Cancer Center Training Program in Drug DevelopmentT32CA121938 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Bouvet, Dwayne G. Stupack · 2006 to 2026
$10.3M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Regulation of Tumor Invasion and Metastasis by Matrix StiffnessR01CA174869 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jing Yang · 2015 to 2026
$4.3M
EPHA2 Receptor Signaling in Breast Cancer MechanotransductionR01CA262794 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE, Jing Yang · 2022 to 2026
$2.9M
Functional interplay between Hippo and estrogen receptor ESR1R01CA268179 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jing Yang · 2022 to 2026
$2.1M
Apical-basal polarity in tumor progression and metastasisR01CA236386 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YANG, JING · 2019 to 2023
$1.9M
Sugar Probed SRS Volumetric imaging of Metabolic ActivitiesR01GM149976 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Lingyan Shi · 2023 to 2026
$1.6M
Novel Optical Imaging Approach to Study Neurovascular Coupling SystemR21NS125395 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHI, LINGYAN · 2022 to 2022
$435k
NCI NIH HHS R01 CA174869NCI NIH HHS R01 CA236386NCI NIH HHS R01 CA262794NCI NIH HHS R01 CA268179NCI NIH HHS T32 CA121938NCI NIH HHS U54 CA274502NIAID NIH HHS U01 AI167892NIGMS NIH HHS R01 GM149976NINDS NIH HHS P30 NS047101NINDS NIH HHS R21 NS125395
6 · The paper itself

Abstract

Contact with dense collagen I (Col1) can induce collective invasion of triple negative breast cancer (TNBC) cells and transcriptional signatures linked to poor patient prognosis. However, this response is heterogeneous and not well understood. Using phenotype-guided sequencing analysis of invasive vs. noninvasive subpopulations, we show that these two phenotypes represent opposite sides of the iron response protein 1 (IRP1)-mediated response to cytoplasmic labile iron pool (cLIP) levels. Invasive cells upregulate iron uptake and utilization machinery characteristic of a low cLIP response, which includes contractility regulating genes that drive migration. Non-invasive cells upregulate iron sequestration machinery characteristic of a high cLIP response, which is accompanied by upregulation of actin sequestration genes. These divergent IRP1 responses result from Col1-induced transient expression of heme oxygenase I (HO-1), which cleaves heme and releases iron. These findings lend insight into the emerging theory that heme and iron fluxes regulate TNBC aggressiveness.

Indexed as

CancerCell biologyMolecular biologyMolecular physiology

Identifiers

PMID39262774
PMCPMC11387597

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.