Evidence map›Paper›PMID 39262692›Full record

ArticleAmerican journal of translational research2024

Prognostic value of NT-proBNP and uric acid in acute ST-segment elevation myocardial infarction patients after complete revascularization.

Li Kang, Denghai Xie, Dandan Chen, Chunwei Wu

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Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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2 citing papers in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Li KangHealth Management Center, The Affiliated Hospital of Guizhou Medical University Guiyang 550004, Guizhou, China.
Denghai XieDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University Guiyang 550004, Guizhou, China.
Dandan ChenGuizhou Medical University Guiyang 550004, Guizhou, China.
Chunwei WuHealth Management Center, The Affiliated Hospital of Guizhou Medical University Guiyang 550004, Guizhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and uric acid (UA) in acute ST-segment elevation myocardial infarction (STEMI) patients after complete revascularization (CR).

methodsThe clinical and physical data from 125 acute STEMI patients (research group) who underwent CR between December 2017 and December 2020 and 60 healthy individuals (control group) who concurrently underwent physical examinations in the Affiliated Hospital of Guizhou Medical University were retrospectively analyzed in this study. Serum samples were collected from both groups to determine the levels of NT-proBNP and UA. The 3-year follow-up data of acute STEMI patients were collected, which were used to group the patients into a good and a poor prognosis group based on their prognoses to comparatively analyze NT-proBNP and UA levels. Receiver operating characteristic (ROC) curves were drawn to analyze the prognostic value of NT-proBNP and UA in STEMI patients following CR, and survival curves were plotted to observe their influences on patients' 3-year overall survival (OS). Meanwhile, a univariate analysis was conducted to identify factors associated with the 3-year OS of acute STEMI patients after CR.

resultsThe data showed significantly higher expression levels of serum NT-proBNP and UA in acute STEMI patients than in the controls. Besides, the good prognosis group exhibited markedly lower serum NT-proBNP and UA levels than the poor prognosis group. The areas under the curve (AUCs) of NT-proBNP and UA in predicting the prognosis of acute STEMI patients after CR were all above 0.700, and the AUC of their combined detection reached over 0.800. In addition, high serum NT-proBNP and UA levels were strongly associated with lower 3-year OS rates. As indicated by the univariate analysis, a history of smoking and alcoholism as well as high NT-proBNP and UA levels were closely associated with 3-year OS in acute STEMI patients after CR.

conclusionsNT-proBNP and UA have promising prognostic value in acute STEMI after CR.

Indexed as

acute ST segment elevationcomplete revascularizationmyocardial infarctionNT-proBNPpredicted valueUA

Identifiers

PMID39262692
PMCPMC11384352

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