Evidence map›Paper›PMID 39262442›Full record

ArticleAntibody therapeutics2024

First site-specific conjugation method for native goat IgG antibodies via glycan remodeling at the conserved Fc region.

Michael E Dolan, Amissi Sadiki, Leo Lei Wang, Yan Wang, Christopher Barton, Sheldon F Oppenheim, Zhaohui Sunny Zhou

Abstract read
In one paragraph

Article in Antibody therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael E DolanDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States.ORCID https://orcid.org/0009-0009-4497-8725
Amissi SadikiDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States.ORCID https://orcid.org/0000-0003-3117-5682
Leo Lei WangAnalytical Development, Takeda Development Center Americas, 200 Shire Way, Lexington, MA 02421, United States.ORCID https://orcid.org/0000-0002-3625-506X
Yan WangAnalytical Development, Takeda Development Center Americas, 200 Shire Way, Lexington, MA 02421, United States.
Christopher BartonAnalytical Development, Takeda Development Center Americas, 200 Shire Way, Lexington, MA 02421, United States.
Sheldon F OppenheimBiotherapeutics Process Development, Takeda Development Center Americas, 200 Shire Way, Lexington, MA 02421, United States.
Zhaohui Sunny ZhouDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States.ORCID https://orcid.org/0000-0003-1645-7411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite their triumph in treating human diseases, antibody therapies for animals have gained momentum more slowly. However, the first approvals of animal antibodies for osteoarthritic pain in cats and dogs may herald the dawn of a new era. For example, goats are vital to economies around the world for their milk, meat, and hide products. It is therefore imperative to develop therapies to safeguard goats-with antibodies at the forefront. Goat antibodies will be crucial in the development of therapeutic antibodies, for example, as tracers to study antibody distribution

Indexed as

AntibodyPlusglycan-mediated conjugationglycan remodelinggoat antibodygreen fluorescent protein (GFP)phospholipase B-like 2 (PLBL2)site-specific conjugation

Identifiers

PMID39262442
PMCPMC11384149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.