Evidence map›Paper›PMID 39262337›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Transvenous phrenic nerve stimulation reduces diaphragm injury during controlled mechanical ventilation in a preclinical model of ARDS.

Elizabeth C Rohrs, Karl C Fernandez, Thiago G Bassi, Michelle Nicholas, Jessica Wittmann, Marlena Ornowska, Matt Gani, Isabella Dakin, Steven C Reynolds

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth C RohrsSimon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0003-1128-4443
Karl C FernandezSimon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0002-9518-2323
Thiago G BassiSimon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0001-5570-5057
Michelle NicholasSimon Fraser University, Burnaby, British Columbia, Canada.
Jessica WittmannRCHF Advancing Innovation in Medicine Institute, New Westminster, British Columbia, Canada.
Marlena OrnowskaSimon Fraser University, Burnaby, British Columbia, Canada.
Matt GaniLungpacer Medical USA, Inc., Exton, Pennsylvania, United States.
Isabella DakinMcGill University, Montreal, Quebec, Canada.
Steven C ReynoldsSimon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0002-2624-640X

Funding

BC Lung AssociationLungpacer Medical Inc.Royal Columbian Hospital FoundationTB Vets Foundation
6 · The paper itself

Abstract

Patients with acute respiratory distress syndrome (ARDS) require periods of deep sedation and mechanical ventilation, leading to diaphragm dysfunction. Our study seeks to determine whether the combination of temporary transvenous diaphragm neurostimulation (TTDN) and mechanical ventilation changes the degree of diaphragm injury and cytokines concentration in a preclinical ARDS model. Moderate ARDS was induced in pigs using oleic acid, followed by ventilation for 12 h post-injury with volume-control at 8 mL/kg, positive end-expiratory pressure (PEEP) 5 cmH

Indexed as

CytokinesDiaphragmDisease Models, AnimalPhrenic NerveRespiration, ArtificialRespiratory Distress SyndromeAnimalsElectric Stimulation TherapyFemaleMalePositive-Pressure RespirationSwineCytokinesARDSdiaphragm injurymechanical ventilationphrenic nerve stimulation

Identifiers

PMID39262337
PMCPMC11573254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.