Evidence map›Paper›PMID 39262129›Full record

ArticleJournal of peptide science : an official publication of the European Peptide Society2025

Combination of the amide-to-triazole substitution strategy with alternative structural modifications for the metabolic stabilization of tumor-targeting, radiolabeled peptides.

Xabier Guarrochena, Maximilian Anderla, Philipp Salomon, Irene V J Feiner, Berthold A Nock, Theodosia Maina, Thomas L Mindt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of peptide science : an official publication of the European Peptide Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xabier GuarrochenaInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Maximilian AnderlaInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Philipp SalomonInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Irene V J FeinerInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-6938-9745
Berthold A NockMolecular Radiopharmacy, INRaSTES, NCSR "Demokritos", Athens, Greece.
Theodosia MainaMolecular Radiopharmacy, INRaSTES, NCSR "Demokritos", Athens, Greece.ORCID https://orcid.org/0000-0002-1123-2486
Thomas L MindtInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.

Funding

Austrian Science Fund P 31477-B28
6 · The paper itself

Abstract

Radiolabeled peptides play a key role in nuclear medicine to selectively deliver radionuclides to malignancies for diagnosis (imaging) and therapy. Yet, their efficiency is often compromised by low metabolic stability. The use of 1,4-disubstituted 1,2,3-triazoles (1,4-Tzs) as stable amide bond bioisosteres can increase the half-life of peptides in vivo while maintaining their biological properties. Previously, the amide-to-triazole substitution strategy was used for the stabilization of the pansomatostatin radioligand [

Indexed as

AmidesRadiopharmaceuticalsTriazolesAnimalsHumansMiceNeoplasmsPeptidesPeptidomimeticsTissue DistributionAmidesPeptidesPeptidomimeticsRadiopharmaceuticalsTriazolesbioisosteresCuAACpeptide‐based radiotracerproteolytic stabilitysomatostatintriazolo‐peptidomimetic

Identifiers

PMID39262129
PMCPMC11602245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.