Evidence map›Paper›PMID 39262097›Full record

ArticleMovement disorders clinical practice2024

Unveiling the Dominant Factors in Subthalamic Stimulation for Improving Depression in Parkinson's Disease.

Guangrui Zhao, Yifeng Cheng, Guangfeng Li, Lanxin Li, Feng Li, Yuzhang Wu, Chuan Du, Jingtao Yan, Guangyan Cong, Qiyuan Zhao and 3 more

Abstract read
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In one paragraph

Article in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Guangrui ZhaoClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0003-0408-1090
Yifeng ChengClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Guangfeng LiClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Lanxin LiDepartment of Neurology, Huanhu Hospital, Tianjin University, Tianjin, China.
Feng LiDepartment of Neurology, Drum Tower Clinical College, Nanjing University of Traditional Chinese Medicine, Nanjing, China.
Yuzhang WuClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Chuan DuClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Jingtao YanClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Guangyan CongDepartment of Neurology, Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, China.
Qiyuan ZhaoDepartment of Neurology, Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, China.
Min WangDepartment of Neurosurgery, Huanhu Hospital, Tianjin University, Tianjin, China.
Keke FengClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Shaoya YinClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.

Funding

Natural Science Foundation of Tianjin Municipality 20JCYBJC00930Natural Science Foundation of Tianjin Municipality 21JCYBJC00450Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-052B
6 · The paper itself

Abstract

backgroundCurrently, the conclusions of studies on subthalamic nucleus (STN) deep brain stimulation (DBS) for improving Parkinson's disease (PD) with depression are inconsistent, and the reasons for improvement or deterioration remain unclear.

methodsThe aim was to investigate the prognosis of PD with depression after bilateral STN-DBS and the factors related to the improvement in depression. The local and network effects of DBS on depression in PD (DPD) were further explored based on the volume of tissue activation (VTA). The study analyzed 80 primary PD patients who had undergone bilateral STN-DBS, comprising 47 patients with improved depression and 33 patients without improvement. Two groups of clinical profiles and stimulation parameters were compared, and the network models for improving depression were constructed.

resultsThe improvement in depression was closely associated with improvement in anxiety (odd rate [OR] = 1.067, P = 0.006) and the standardized space left y-coordinate (OR = 0.253, P = 0.005). The VTA overlapping with the left motor STN subregion is most significantly associated with improvement in depression (R

conclusionThe amelioration of DPD is primarily attributed to the stimulation of bilateral motor STN, particularly on the left. However, this stimulatory effect manifests as an indirect influence.

Indexed as

Deep Brain StimulationDepressionParkinson DiseaseSubthalamic NucleusAgedFemaleHumansMaleMiddle AgedTreatment Outcomedeep brain stimulationdepressionnetwork effectsParkinson's diseasesubthalamic nucleus

Identifiers

PMID39262097
PMCPMC11647981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.