Evidence map›Paper›PMID 39261989›Full record

ReviewEar and hearing

Roadmap to a Global Template for Implementation of Ototoxicity Management for Cancer Treatment.

Katharine Fernandez, Alex Hoetink, Dawn Konrad-Martin, Deborah Berndtson, Khaya Clark, Laura Dreisbach, James I Geller, Maria Valeria Goffi-Gomez, Amy Grosnik, Carmen Jamis and 12 more

Abstract readReview
In one paragraph

Review in Ear and hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Katharine FernandezDivision of Intramural Research, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA.
Alex HoetinkDepartment of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Dawn Konrad-MartinNational Center for Rehabilitative Auditory Research, Veterans Affairs Rehabilitation Research and Development, Veterans Affairs Portland Health Care System, Portland, Oregon, USA.
Deborah BerndtsonInternational Ototoxicity Management Group, Cancer Survivor and Advocate, Vienna, Virginia, USA.
Khaya ClarkNational Center for Rehabilitative Auditory Research, Veterans Affairs Rehabilitation Research and Development, Veterans Affairs Portland Health Care System, Portland, Oregon, USA.
Laura DreisbachSchool of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, California, USA.
James I GellerDivision of Audiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Maria Valeria Goffi-GomezDivision of Audiology, AC Camargo Cancer Center, São Paulo, Brazil.
Amy GrosnikDivision of Audiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Carmen JamisHead and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Kristin KnightDepartment of Audiology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA.
David S LeeDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
John LeeDivision of Intramural Research, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA.
Patricia Helena Pecora LibermanDivision of Audiology, AC Camargo Cancer Center, São Paulo, Brazil.
Trisha MilnesDepartment of Audiology, Veterans Affairs Augusta Health Care System, Augusta, Georgia, USA.
Annelot J M MeijerAudiology, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Candice E OrtizCapital Institute of Hearing & Balance, Silver Spring, Maryland, USA.
Jennessa RookerCollege of Nursing, University of South Florida, Tampa, Florida, USA.
Victoria A SanchezDepartment of Otolaryngology-Head & Neck Surgery, University of South Florida, Tampa, Florida, USA.
Mary M van den Heuvel-EibrinkAudiology, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Carmen C BrewerDivision of Intramural Research, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA.
Gayla L PolingDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Funding

Mechanisms of Sensory Hair Cell Survival and DeathZIADC000079 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI CUNNINGHAM, LISA L · 2011 to 2025
$27.2M
Clinical Analysis Of Disorders Of Hearing And BalanceZIADC000064 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI HERTZANO, RONNA · 2009 to 2025
$25.2M
Intramural NIH HHS ZIA DC000064Intramural NIH HHS ZIA DC000079RRD VA I01 RX003127RRD VA IK6 RX005044
6 · The paper itself

Abstract

Ototoxicity is among the adverse events related to cancer treatment that can have far-reaching consequences and negative impacts on quality-of-life for cancer patients and survivors of all ages. Ototoxicity management (OtoM) comprises the prevention, diagnosis, monitoring, and treatment, including rehabilitation and therapeutic intervention, of individuals who experience hearing loss, tinnitus, or balance/vestibular difficulties following exposures to ototoxic agents, including platinum chemotherapy (cisplatin, carboplatin) and cranial radiation. Despite the well-established physical, socioeconomic, and psychological consequences of hearing and balance dysfunction, there are no widely adopted standards for clinical management of cancer treatment-related ototoxicity. Consensus recommendations and a roadmap are needed to guide development of effective and feasible OtoM programs, direct research efforts, address the needs of caregivers and patients at all stages of cancer care and survivorship. Here we review current evidence and propose near-term to longer-term goals to advance OtoM in five strategic areas: (1) beneficiary awareness, empowerment, and engagement, (2) workforce enhancement, (3) program development, (4) policy, funding, and sustainability, and (5) research and evaluation. The goal is to identify needs and establish a roadmap to guide worldwide adoption of standardized OtoM for cancer treatment and improved outcomes for patients and survivors.

Indexed as

Antineoplastic AgentsHearing LossNeoplasmsOtotoxicityCarboplatinCisplatinHumansTinnitusAntineoplastic AgentsCarboplatinCisplatin

Identifiers

PMID39261989
PMCPMC11832334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.