Evidence map›Paper›PMID 39261949›Full record

ArticleTrials2024

Reducing pain by improving brain and muscle activity with motor cortical neuromodulation in women with interstitial cystitis/bladder pain syndrome: a study protocol for a randomized controlled trial.

Eileen V Johnson, Molly Bachmann, Moheb S Yani, Sandrah P Eckel, Giselle I Garcia, Larissa V Rodriguez, Jason J Kutch

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04734847 (Motor Cortical Neuromodulation in Women With Interstitial Cystitis/Bladder Pain Syndrome), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04734847 naactive not recruitingnot on this map

Motor Cortical Neuromodulation in Women With Interstitial Cystitis/Bladder Pain Syndrome: Reducing Pain by Improving Brain and Muscle Activity

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2021 to 2026Enrolled50ConditionsInterstitial Cystitis, Bladder Pain SyndromeArmsRepetitive Transcranial Magnetic Stimulation (rTMS), Sham Repetitive Transcranial Magnetic Stimulation (Sham-rTMS)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eileen V JohnsonDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, USA. eileenjo@pt.usc.edu.
Molly BachmannDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, USA.
Moheb S YaniDavid Geffen School of Medicine, University of California, Los Angeles, USA.
Sandrah P EckelPopulation and Public Health Sciences, University of Southern California, Los Angeles, USA.
Giselle I GarciaDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, USA.
Larissa V RodriguezDepartment of Urology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jason J KutchDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, USA.

Funding

Motor cortical neuromodulation in women with Interstitial Cystitis/Bladder Pain Syndrome: reducing pain by improving brain and muscle activityR01DK121724 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KUTCH, JASON J., RODRIGUEZ, LARISSA · 2020 to 2024
$2.4M
NIDDK NIH HHS R01 DK121724
6 · The paper itself

Abstract

introductionInterstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain condition creating a wide range of urologic and pain symptoms. There is currently limited evidence to understand the mechanisms of IC/BPS. There have been recent studies suggesting that altered function in brain motor areas, particularly the supplementary motor cortex (SMA), relates to altered bladder sensorimotor control and may play an important role in IC/BPS. This study aims to provide evidence that non-invasive stimulation targeting the motor cortex may help reduce IC/BPS pain, as well as better understand the neural mechanism by which this stimulation targets neuromuscular dysfunction. This study is a two-group quadruple-blinded randomized controlled trial (RCT) of active vs. sham repetitive transmagnetic stimulation (rTMS). In addition, our study will also include functional magnetic resonance imaging (fMRI), pelvic floor electromyography (EMG), pelvic exam, and outcome measures and questionnaires to further study outcomes. ETHICS AND DISSEMINATION: All aspects of the study were approved by the Institutional Review Board of the University of Southern California (protocol HS-20-01021). All participants provided informed consent by the research coordinator/assistants. The results will be submitted for publication in peer-reviewed journals and disseminated at scientific conferences.

trial registrationClinicalTrials.gov NCT04734847. Registered on February 1, 2021.

Indexed as

Cystitis, InterstitialMotor CortexRandomized Controlled Trials as TopicTranscranial Magnetic StimulationAdultElectromyographyFemaleHumansMagnetic Resonance ImagingMiddle AgedPain ManagementPain MeasurementPelvic FloorTreatment OutcomeUrinary BladderBladder pain syndromeBPSChronic overlapping pain conditionChronic painFunctional magnetic resonance imagingICInterstitial cystitisMotor cortical neuromodulationPelvic floor musclesPelvic painSupplementary motor areaTranscranial magnetic stimulation

Identifiers

PMID39261949
PMCPMC11391754

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.