ArticleFluids and barriers of the CNS2024
Coupled pulsatile vascular and paravascular fluid dynamics in the human brain.
Article in Fluids and barriers of the CNS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- TRACC-PHYSIO: Time-Domain Resolution-Aligned Cross-Correlation to Estimate PHYSIOlogical Coupling and Time Delays in Dynamic MRI.Magnetic resonance in medicine · 2026Article
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Simultaneous Assessment of Intracranial Artery and Paravascular CSF Pulsation Using 3D Whole-Brain Diffusion-Prepared Cine bSSFP (DECAF) MRI.Magnetic resonance in medicine · 2026Article
- MRI-based evidence of rectus capitis posterior minor hypertrophy and its correlation with disease duration in Parkinson's disease.BMC medical imaging · 2026Article
- Combined ipsilateral peak systolic velocity and ASPECTS are associated with early neurological deterioration after endovascular thrombectomy: a prospective cohort study.BMC neurology · 2026Article
- Cerebrospinal fluid mechanics across CNS barriers: from production, circulation, and clearance to mechanomedicine.Frontiers in neuroscience · 2026Review
- Dynamic DWI detects respiratory modulation of brain parenchymal hydrodynamics.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Imaging blood to periarterial CSF flow coupling using 4D flow MRI and an ultra-high-performance head-only gradient system.Fluids and barriers of the CNS · 2025Article
- Quantitative evaluation of low-frequency oscillations using real-time phase-contrast MRI during drowsiness.Fluids and barriers of the CNS · 2025Article
- HyPER: Region-specific hypersampling of fMRI to resolve low-frequency, respiratory, and cardiac pulsations, revealing age-related differences.NeuroImage · 2025Article
- Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- The aging human brain exhibits reduced cerebrospinal fluid flow during sleep due to both neural and vascular factors.bioRxiv : the preprint server for biology · 2025Article
- HybridFormer: a convolutional neural network-Transformer architecture for low dose computed tomography image denoising.PeerJ. Computer science · 2025Article
- An fMRI approach to assess intracranial arterial-to-venous cardiac pulse delay in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Brain glymphatic fluid mapping in Alzheimer's disease: a human MRI and PET study.Brain communications · 2025Article
- Simultaneous and synchronous characterization of blood and CSF flow dynamics using multiple Venc PC MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Robust data-driven segmentation of pulsatile cerebral vessels using functional magnetic resonance imaging.Interface focus · 2024Article
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7 authors.
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Abstract
backgroundCardiac pulsation propels blood through the cerebrovascular network to maintain cerebral homeostasis. The cerebrovascular network is uniquely surrounded by paravascular cerebrospinal fluid (pCSF), which plays a crucial role in waste removal, and its flow is suspected to be driven by arterial pulsations. Despite its importance, the relationship between vascular and paravascular fluid dynamics throughout the cardiac cycle remains poorly understood in humans.
methodsIn this study, we developed a non-invasive neuroimaging approach to investigate the coupling between pulsatile vascular and pCSF dynamics within the subarachnoid space of the human brain. Resting-state functional MRI (fMRI) and dynamic diffusion-weighted imaging (dynDWI) were retrospectively cardiac-aligned to represent cerebral hemodynamics and pCSF motion, respectively. We measured the time between peaks (∆TTP) in
resultsHemodynamic changes consistently precede pCSF motion. ∆TTP was significantly shorter in younger adults compared to older adults (-0.015 vs. -0.069, p < 0.05). The correlation at aligned peaks were high and did not differ between younger and older adults (0.833 vs. 0.776, p = 0.153). The ∆TTP and correlation at aligned peaks were robust across fMRI protocols (∆TTP: -0.15 vs. -0.053, p = 0.239; correlation at aligned peaks: 0.813 vs. 0.812, p = 0.985) and demonstrated good to excellent within-subject reproducibility (∆TTP: intraclass correlation coefficient = 0.36; correlation at aligned peaks: intraclass correlation coefficient = 0.89).
conclusionThis study proposes a non-invasive technique to evaluate vascular and paravascular fluid dynamics. Our findings reveal a consistent and robust cardiac pulsation-driven coupling between cerebral hemodynamics and pCSF dynamics in both younger and older adults.
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