ArticleBMC endocrine disorders2024
Association between 25 hydroxyvitamin D and serum uric acid level in the Chinese general population: a cross-sectional study.
Article in BMC endocrine disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association between vitamin D and serum uric acid in a large Chinese cohort of middle-aged and elderly Chinese men and women.Frontiers in nutrition · 2026Article
- Non-Linear Associations Between Serum Vitamin D and Uric Acid in Korean Adults: 2022-2023 KNHANES Data.Nutrients · 2025Article
- Serum uric acid/creatinine ratio and osteoporosis in the elderly: a NHANES study.Frontiers in medicine · 2025Article
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4 authors.
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Abstract
backgroudThe relationship between serum uric acid (SUA) and 25-hydroxyvitamin D (25(OH)D) has been variably characterized in existing literature, with inconsistent results regarding its nature and implications in the Chinese population. This study aims to clarify this association, considering the potential impact of vitamin D levels on SUA.
methodsThis cross-sectional study involved 7,086 individuals from the Second Affiliated Hospital of Zhejiang University School of Medicine, screened throughout 2020. We collected data on 25(OH)D, SUA, and other metabolic markers. Logistic regression models adjusted for confounding factors were utilized to analyze the relationships.
resultsOur findings illustrate a statistically significant inverted U-shaped relationship between 25(OH)D and SUA. The identified threshold effect at 28.82 ng/ml is pivotal; with 25(OH)D levels below this point associated with an increased risk of hyperuricemia (odds ratio: 1.0146, p = 0.0148), and levels above it offering protective benefits (odds ratio: 0.9616, p = 0.0164).
conclusionsOur findings confirm a nonlinear, inverted U-shaped correlation between 25(OH)D and SUA, emphasizing the importance of maintaining vitamin D levels within a specific range to effectively manage hyperuricemia. These results support the implementation of personalized vitamin D supplementation strategies to optimize metabolic health outcomes, highlighting the complex interplay between vitamin D status and uric acid levels.
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