Evidence map›Paper›PMID 39261798›Full record

Trial reportBMC anesthesiology2024

Efficacy of ozonated autohemotherapy for improvement of myocardial injury following traumatic brain injury.

Chenhao Wang, Yi Zhu, Wei Liu, Lingyun Ren, Zhouquan Wu, Jingli Chen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenhao Wang *Department of Anesthesiology, Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430000, Hubei Province, China.
Yi Zhu *Department of Anesthesiology, Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430000, Hubei Province, China.
Wei LiuDepartment of Anesthesiology, Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430000, Hubei Province, China.
Lingyun RenDepartment of Anesthesiology, Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430000, Hubei Province, China.
Zhouquan WuDepartment of Anesthesiology, Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou, 213000, Jiangsu Province, China. wuzhouquan2005@126.com.
Jingli ChenDepartment of Anesthesiology, Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, 430000, Hubei Province, China. chenjinli2001@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraumatic brain injury is a kind of injury caused by external violence on the head. Its danger is not limited to life rescue in the early stage of the disease. Moreover, the subsequent inflammatory reaction and the change in its oxidative stress level will cause secondary myocardial injury. The purpose of this study is to explore the myocardial protective effect of ozone autohemotherapy (OA) in the progression of acute traumatic brain injury (TBI).

methodsForty patients with acute TBI were recruited and divided into The treatment group (Group OA, n = 18) and the Control group (Group C, n = 19). Patients in Group OA received OA before surgery and on the 1st and 2nd postoperative days, while patients in Group C underwent autologous blood transfusion. Venous blood was collected from all patients before (T0) and after 7 days (T1) days of surgery for measurement of cardiac troponin T (cTnT) and amino-terminal pro-B-type natriuretic peptide (NT-proBNP). At T0 and T1, transthoracic cardiac ultrasound was performed to measure left ventricular ejection fraction (LVEF), tricuspid annular plane systolic excursion (TAPSE), and venous blood was sampled to determine the contents of superoxide dismutase (SOD) and malondialdehyde (MDA). NIH Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS) scores were calculated, and other clinical indexes were recorded.

results(1) The levels of cTnT at T1 were significantly higher as compared with that at T0 in both groups (p < 0.01). Compared with Group C, a remarkable decline in the content of NT-proBNP was found in Group OA at T1 (p = 0.021). (2) The LVEF (p = 0.002) and serum SOD (p = 0.015) at T1 were significantly increased in Group OA as compared with those in Group C. (3) The length of Intensive Care Unit and hospitalization time for patients in Group OA was distinctly shorter than that for patients in Group C (p = 0.021, p = 0.015, respectively).

conclusionPerioperative OA treatment can alleviate the secondary myocardial injury during the disease course of TBI, which might be associated with its myocardial protective effect against oxidative stress.

trial registrationThis study was approved by the Ethical Committee of Changzhou NO.2 People's Hospital. The protocol was registered prospectively with the Chinese Clinical Trial Registry (ChiCTR2000029612) on February 02, 2020.

Indexed as

Blood Transfusion, AutologousBrain Injuries, TraumaticNatriuretic Peptide, BrainOzoneAdultFemaleHumansMaleMalondialdehydeMiddle AgedOxidative StressPeptide FragmentsSuperoxide DismutaseTroponin TMalondialdehydeNatriuretic Peptide, BrainOzonePeptide Fragmentspro-brain natriuretic peptide (1-76)Superoxide DismutaseTroponin TAcute traumatic brain injuryMyocardial protectionOxidative stressOzonated autohemotherapy

Identifiers

PMID39261798
PMCPMC11389279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.