Evidence map›Paper›PMID 39261770›Full record

ArticleBMC geriatrics2024

Sarcopenia as a predictor of nutritional status and comorbidities: a cross-sectional and mendelian randomization study.

Chao Liu, Guanyi Chen, Yu Xia, Pingxiao Wang, Ziyue Zhao, JiaLin Zhang, Tao Xiao, Hui Li

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In one paragraph

Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chao LiuDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan , 410011, People's Republic of China.
Guanyi ChenDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan , 410011, People's Republic of China.
Yu XiaDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan , 410011, People's Republic of China.
Pingxiao WangDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan , 410011, People's Republic of China.
Ziyue ZhaoDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan , 410011, People's Republic of China.
JiaLin ZhangDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan , 410011, People's Republic of China.
Tao XiaoDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan , 410011, People's Republic of China.
Hui LiDepartment of Orthopedics, the Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan , 410011, People's Republic of China. lihuix@csu.edu.cn.ORCID http://orcid.org/0000-0003-4759-1779

Funding

Research Project of Human Health Commission 202204073071
6 · The paper itself

Abstract

backgroundWith the advancement of world population aging, age-related sarcopenia (SP) imposes enormous clinical burden on hospital. Clinical research of SP in non-geriatric wards has not been appreciated, necessitating further investigation. However, observational studies are susceptible to confounders. Mendelian randomization (MR) can effectively mitigate bias to assess causality.

objectiveTo investigate the correlation between SP and comorbidities in orthopedic wards, and subsequently infer the causality, providing a theoretical basis for developing strategies in SP prevention and treatment.

methodsLogistic regression models were employed to assess the correlation between SP and comorbidities. The MR analysis was mainly conducted with inverse variance weighted, utilizing data extracted from the UK and FinnGen biobank (Round 9).

resultsIn the cross-sectional analysis, SP exhibited significant associations with malnutrition (P = 0.013) and some comorbidities, including osteoporosis (P = 0.014), body mass index (BMI) (P = 0.021), Charlson Comorbidity Index (CCI) (P = 0.006). The MR result also provided supporting evidence for the causality between SP and hypertension, osteoporosis and BMI. These results also withstood multiple sensitivity analyses assessing the validity of MR assumptions.

conclusionThe result indicated a significant association between SP and BMI, CCI, malnutrition, and osteoporosis. We highlighted that SP and comorbidities deserved more attention in non-geriatric wards, urging further comprehensive investigation.

Indexed as

ComorbidityMendelian Randomization AnalysisNutritional StatusSarcopeniaAgedAged, 80 and overBody Mass IndexCross-Sectional StudiesFemaleHumansMaleMiddle AgedOsteoporosisComorbidityMalnutritionMendelian randomizationOsteoporosisSarcopenia

Identifiers

PMID39261770
PMCPMC11389292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.