ArticleNature2024
Genetic links between ovarian ageing, cancer risk and de novo mutation rates.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Consideration of inherited cancer risk on a continuum: An international and multidisciplinary perspective: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG).Genetics in medicine : official journal of the American College of Medical Genetics · 2026Guideline
- Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases.Nature communications · 2025Pooled it
- Protective effects of ginseng against reproductive injury: mechanisms and research progress.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Structural elements required for the efficient loading and activation of HELB on RPA-coated single-stranded DNA.bioRxiv : the preprint server for biology · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.MedComm · 2026Review
- Large-scale analysis of FMR1 CGG repeat length and risk of premature ovarian insufficiency in over 92 000 women.Human reproduction (Oxford, England) · 2026Article
- Natural menopause, menarche and breast cancer risk in BRCA1 and BRCA2 pathogenic variant carriers: a Mendelian randomization analysis.British journal of cancer · 2026Article
- Reproductive Fitness and the Links to Chronic Disease and Systemic Aging.Physiology (Bethesda, Md.) · 2026Review
- Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs.Nature aging · 2026Article
- A novel role of tRNA-derived fragments in porcine granulosa-oocyte cell communication and cuproptosis.PLoS genetics · 2026Article
- The Role of Neutrophil Extracellular Traps (NETs) in the Pathogenesis of Ovarian Cancer: New Insight and Future Perspectives.Molecular biotechnology · 2026Review
- Reproductive medicine care in BRCA mutation carriers: an opportunity for early intervention.F&S reports · 2026Article
- SPICEY: an R package for quantifying tissue specificity from single cell multi-omics data.BMC bioinformatics · 2026Article
- Article
- Mechanisms of human germ cell development.Nature reviews. Molecular cell biology · 2026Review
- Research Hotspots and Emerging Frontiers in Ovarian Aging: A Bibliometric Analysis (2006-2025).Endocrine, metabolic & immune disorders drug targets · 2026Review
- Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality.npj women's health · 2026Review
- Multi-omics signatures of chronic inflammation across immune-related disease states.Frontiers in immunology · 2026Article
- Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause.JCI insight · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Stasa Stankovic *MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6602-1379
Saleh Shekari *University of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0002-1727-0272
Qin Qin Huang *Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0003-3073-717X
Eugene J Gardner *MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9671-1533
Erna V Ivarsdottir *deCODE Genetics/Amgen, Reykjavik, Iceland.
Nick D L Owens *University of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0002-2151-9923
Nasim MavaddatCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Ajuna AzadDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gareth HawkesUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0002-3367-789X
Katherine A KentistouMRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5816-664X
Robin N BeaumontUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0003-0750-8248
Felix R DayMRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3789-7651
Yajie ZhaoMRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2747-0219
Hakon JonssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Thorunn RafnardeCODE Genetics/Amgen, Reykjavik, Iceland.
Vinicius TragantedeCODE Genetics/Amgen, Reykjavik, Iceland.
Gardar SveinbjornssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Asmundur OddssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Unnur StyrkarsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.
Julius GudmundssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Simon N StaceydeCODE Genetics/Amgen, Reykjavik, Iceland.
Daniel F GudbjartssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Breast Cancer Association Consortium
Kitale KennedyUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Andrew R WoodUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0003-1726-948X
Michael N WeedonUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0002-6174-6135
Ken K OngMRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4689-7530
Caroline F WrightUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0003-2958-5076
Eva R HoffmannDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Patrick SulemdeCODE Genetics/Amgen, Reykjavik, Iceland.
Matthew E HurlesWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-2333-7015
Katherine S RuthUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0003-4966-9170
Hilary C Martin *Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-4454-9084
Kari Stefansson *deCODE Genetics/Amgen, Reykjavik, Iceland.
John R B Perry *MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.ORCID 0000-0001-6483-3771
Anna Murray *University of Exeter Medical School, University of Exeter, Exeter, UK. A.Murray@exeter.ac.uk.ORCID 0000-0002-2351-2522
Funding
Wellcome Trust
Abstract
Human genetic studies of common variants have provided substantial insight into the biological mechanisms that govern ovarian ageing
Indexed as
AgingGenetic Predisposition to DiseaseMenopauseMutation RateNeoplasmsOvaryAdultDNA DamageFemaleFertilityGenetic VariationGenome, HumanGerm-Line MutationHumansMaleMenarche
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.