ArticleNature2024
Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- DNA Repair Mechanisms.Methods in molecular biology (Clifton, N.J.) · 2027Review
- Mechanisms and disease relevance of DNA break repair pathway choice.Nature reviews. Molecular cell biology · 2026Review
- The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss.The EMBO journal · 2026Article
- ADSCs-Exo ameliorates UVB-induced skin DNA damage via p62-RNF168-dependent histone ubiquitination.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- TheBiomolecular NMR assignments · 2026Article
- PCNA-RECQL5-RPRD1B recruit repair components to stressed replication forks to promote survival of BRCA1-deficient cancer cells.Nucleic acids research · 2026Article
- HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination.Nature communications · 2026Article
- HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair.Nature communications · 2026Article
- Insights into Ovarian Cancer: Unraveling the Role of DNA Double-strand Break-related Genes in Pathogenesis and Therapeutic Avenues.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- 53BP1-independent Shieldin-BRCA1 antagonism at replication-coupled double-strand breaks.Nature communications · 2026Article
- G quadruplex DNA facilitates a pervasive path to homologous recombination.bioRxiv : the preprint server for biology · 2026Article
- RYBP regulates selective genomic binding of TrxG and PcG components in embryonic stem cell fate control.The EMBO journal · 2026Article
- BARD1 recognizes pre-rRNA for DNA damage repair and rRNA biogenesis.The Journal of biological chemistry · 2026Article
- TGM2 Regulates Radiosensitivity via POGZ-Mediated Repair of DNA Double-Strand Breaks in Cervical Cancer.Cancer science · 2026Article
- Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1-BARD1 complex.The Journal of biological chemistry · 2026Article
- ssDNA-PLA, a proximity ligation assay to interrogate DNA damage response proteins involved in homologous recombination.Biology methods & protocols · 2026Article
- New twist on BRCA1-mediated DNA recombination repair and tumor suppression.Trends in cell biology · 2026Review
- Targeting ubiquitination in disease and therapy.Signal transduction and targeted therapy · 2025Review
- Plant tolerance mechanisms to DNA-damaging UV stress.Journal of experimental botany · 2025Review
- AQB improves carboplatin sensitivity in endometrial cancer through dual DNA repair modulation: suppression of the p21-E2F1-RAD51 and ATF3-HDAC1-BRCA1 signaling.Cell death & disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Sameer Salunkhe *Department of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-0008-174X
James M Daley *Department of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. daleyj@umich.edu.ORCID 0000-0002-7706-6134
Hardeep Kaur *Department of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Nozomi Tomimatsu *Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Chaoyou Xue *Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-5323-6178
Vivek B RainaDepartment of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Angela M JasperDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-9548-8445
Cody M RogersDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Wenjing LiDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0001-9151-9219
Shuo ZhouDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Rahul MojidraDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-7103-9784
Youngho KwonDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-0287-8795
Qingming FangDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Jae-Hoon JiDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Aida Badamchi ShabestariDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
O'Taveon FitzgeraldDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Hoang DinhDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0009-0009-6065-7219
Bipasha MukherjeeDepartment of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Amyn A HabibDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4164-9028
Robert HromasDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Alexander V MazinDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Elizabeth V WasmuthDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Shaun K OlsenDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-1265-7101
David S LibichDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0001-6492-2803
Daohong ZhouDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Weixing ZhaoDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0001-5746-3696
Eric C GreeneDepartment of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. ecg2108@cumc.columbia.edu.ORCID 0000-0002-7387-824X
Sandeep BurmaDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. burma@uthscsa.edu.ORCID 0000-0001-7057-9845
Patrick SungDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. sungp@uthscsa.edu.ORCID 0000-0003-1396-9040
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1MTRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4MYEAST DNA REPAIR GENES AND PROTEINS OF THE RAD52 GROUPR01ES007061 · NIEHS · YALE UNIVERSITY · PI Patrick Sung · 1995 to 2026
$9.4MMechanisms of DNA Homology-directed Genome Repair and Tumor SuppressionR35CA241801 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SUNG, PATRICK · 2019 to 2025
$6.0MMechanistic Dissection of the Fanconi Anemia Pathway of DNA Damage Response and RR01CA168635 · NCI · YALE UNIVERSITY · PI Gary M Kupfer, Patrick Sung · 2013 to 2026
$5.8MProtein purification instrumentation in support of single molecule studies of genome integrityR35GM118026 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2016 to 2025
$5.7MStructural Biology of the Ubiquitin Conjugation SystemR01GM115568 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI OLSEN, SHAUN · 2015 to 2023
$2.7MHelicase regulation during homologous recombinationR01CA236606 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Eric C Greene · 2019 to 2026
$2.6MStructure and Function of the Essential Cell Cycle Regulator Cdc34R01GM128731 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Shaun Olsen · 2019 to 2026
$2.5MSouth Texas Medical Scientist Training Program (STX-MSTP)T32GM145432 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jose E Cavazos, Ratna K Vadlamudi · 2023 to 2026
$2.3MBimodal EGFR signaling in glioblastomaR01NS119225 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI AMYN HABIB · 2022 to 2026
$2.0MDefining the contributions of BRCA1, BRCA2, and RAD52 to genome stabilityR01CA221858 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2020 to 2024
$1.9MNCI NIH HHS F30 CA278370NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA139429NCI NIH HHS R01 CA168635NCI NIH HHS R01 CA219836NCI NIH HHS R01 CA221858NCI NIH HHS R01 CA236606NCI NIH HHS R01 CA244212NCI NIH HHS R01 CA246807NCI NIH HHS R35 CA241801NCI NIH HHS R50 CA265315NIA NIH HHS T32 AG021890NIEHS NIH HHS R01 ES007061NIGMS NIH HHS R00 GM140264NIGMS NIH HHS R01 GM115568NIGMS NIH HHS R01 GM128731NIGMS NIH HHS R01 GM136717NIGMS NIH HHS R01 GM140127NIGMS NIH HHS R01 GM141091NIGMS NIH HHS R35 GM118026NIGMS NIH HHS T32 GM145432NIH HHS S10 OD030432NINDS NIH HHS R01 NS119225
Abstract
The licensing step of DNA double-strand break repair by homologous recombination entails resection of DNA ends to generate a single-stranded DNA template for assembly of the repair machinery consisting of the RAD51 recombinase and ancillary factors
Indexed as
BRCA1 ProteinDNA Breaks, Double-StrandedExodeoxyribonucleasesHomologous RecombinationRecQ HelicasesTumor Suppressor ProteinsUbiquitin-Protein LigasesDNADNA HelicasesDNA RepairDNA Repair EnzymesDNA, Single-StrandedHumansProtein BindingRad51 RecombinaseRecombinational DNA RepairBARD1 protein, humanBloom syndrome proteinBRCA1 ProteinBRCA1 protein, humanDNADNA2 protein, humanDNA HelicasesDNA Repair EnzymesDNA, Single-StrandedEXO1 protein, humanExodeoxyribonucleasesRad51 RecombinaseRecQ HelicasesTumor Suppressor ProteinsUbiquitin-Protein LigasesWerner Syndrome HelicaseWRN protein, human
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