Evidence map›Paper›PMID 39261702›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2024

Effects of bilateral renal denervation on open-loop baroreflex function and urine excretion in spontaneously hypertensive rats.

Toru Kawada, Masafumi Fukumitsu, Hiroki Matsushita, Yuki Yoshida, Kei Sato, Hidetaka Morita, Takuya Nishikawa, Satoru Suehara, Satoshi Sawada, Keita Saku

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Toru KawadaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan. torukawa@ncvc.go.jp.
Masafumi FukumitsuDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.
Hiroki MatsushitaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.
Yuki YoshidaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.
Kei SatoDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.
Hidetaka MoritaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.
Takuya NishikawaDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center, Osaka, Japan.
Satoru SueharaCorporate R&D Center, Terumo Corporation, Kanagawa, Japan.
Satoshi SawadaCorporate R&D Center, Terumo Corporation, Kanagawa, Japan.
Keita SakuDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bilateral renal denervation (RDN) decreases arterial pressure (AP) or delays the development of hypertension in spontaneously hypertensive rats (SHR), but whether bilateral RDN significantly modifies urine output function during baroreflex-mediated acute AP changes remains unknown. We quantified the relationship between AP and normalized urine flow (nUF) in SHR that underwent bilateral RDN (n = 9) and compared the results with those in sham-operated SHR (n = 9). Moreover, we examined the acute effect of an angiotensin II type 1 receptor blocker telmisartan (2.5 mg/kg) on the AP-nUF relationship. Bilateral RDN significantly decreased AP by narrowing the response range of the total arc of the carotid sinus baroreflex. The slopes of nUF versus the mean AP (in μL·min

Indexed as

BaroreflexKidneyRats, Inbred SHRTelmisartanAngiotensin II Type 1 Receptor BlockersAnimalsBlood PressureDenervationHypertensionMaleRatsAngiotensin II Type 1 Receptor BlockersTelmisartanArterial pressureCarotid sinus baroreflexPressure diuresisRenal denervationSympathetic nerve activity

Identifiers

PMID39261702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.