Evidence map›Paper›PMID 39261580›Full record

ArticleNature microbiology2024

Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis.

Man Ting Au, Junguo Ni, Kaiming Tang, Wei Wang, Lanlan Zhang, Hantang Wang, Fangyi Zhao, Zhan Li, Peng Luo, Lawrence Chun-Man Lau and 10 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Man Ting Au *Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0003-1786-6006
Junguo Ni *Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Kaiming Tang *State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0001-7310-6744
Wei WangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Lanlan ZhangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Hantang WangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Fangyi ZhaoDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Zhan LiDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Peng LuoState Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Lawrence Chun-Man LauDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0002-2245-9627
Ping-Keung ChanDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Cuiting LuoState Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Bo ZhouDepartment of Biology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0003-4213-726X
Lin ZhuState Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0002-2801-3626
Charlie Yuli ZhangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0009-0002-6532-2791
Tianshu JiangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Marianne LauwersDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Jasper Fuk-Woo ChanState Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0001-6336-6657
Shuofeng YuanState Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. yuansf@hku.hk.ORCID http://orcid.org/0000-0001-7996-1119
Chunyi WenDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China. chunyi.wen@polyu.edu.hk.ORCID http://orcid.org/0000-0003-1949-7822

Funding

Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF) 07210107Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF) 16172691National Natural Science Foundation of China (National Science Foundation of China) 32322087, 32300134
6 · The paper itself

Abstract

Joint pain and osteoarthritis can occur as coronavirus disease 2019 (COVID-19) sequelae after infection. However, little is known about the damage to articular cartilage. Here we illustrate knee joint damage after wild-type, Delta and Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vivo. Rapid joint injury with cystic lesions at the osteochondral junction was observed in two patients with post-COVID osteoarthritis and recapitulated in a golden Syrian hamster model. SARS-CoV-2-activated endothelin-1 signalling increased vascular permeability and caused viral spike proteins leakage into the subchondral bone. Osteoclast activation, chondrocyte dropout and cyst formation were confirmed histologically. The US Food and Drug Administration-approved endothelin receptor antagonist, macitentan, mitigated cystic lesions and preserved chondrocyte number in the acute phase of viral infection in hamsters. Delayed macitentan treatment at post-acute infection phase alleviated chondrocyte senescence and restored subchondral bone loss. It is worth noting that it could also attenuate viral spike-induced joint pain. Our work suggests endothelin receptor blockade as a novel therapeutic strategy for post-COVID arthritis.

Indexed as

COVID-19Disease Models, AnimalEndothelin Receptor AntagonistsMesocricetusOsteoarthritisPyrimidinesSARS-CoV-2AnimalsCartilage, ArticularChondrocytesCOVID-19 Drug TreatmentCricetinaeEndothelin-1FemaleHumansMaleEndothelin-1Endothelin Receptor AntagonistsmacitentanPyrimidinesReceptors, EndothelinSpike Glycoprotein, CoronavirusSulfonamides

Identifiers

PMID39261580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.