Evidence map›Paper›PMID 39261069›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Exacerbation of Thyroid Eye Disease and Dysthyroid Optic Neuropathy during Pregnancy.

Masakazu Koshibu, Natsuko Watanabe, Nami Suzuki, Yasuyoshi Takahashi, Hidetoshi Onda, Ai Kozaki, Shigenori Hiruma, Masahiro Ichikawa, Rei Hirose, Hideyuki Imai and 7 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Masakazu KoshibuDepartment of Internal Medicine, Ito Hospital, Japan.
Natsuko WatanabeDepartment of Internal Medicine, Ito Hospital, Japan.
Nami SuzukiDepartment of Internal Medicine, Ito Hospital, Japan.
Yasuyoshi TakahashiDepartment of Internal Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Japan.
Hidetoshi OndaDepartment of Ophthalmology, Showa University School of Medicine, Japan.
Ai KozakiOlympia Eye Hospital, Japan.
Shigenori HirumaDepartment of Internal Medicine, Ito Hospital, Japan.
Masahiro IchikawaDepartment of Internal Medicine, Ito Hospital, Japan.
Rei HiroseDepartment of Internal Medicine, Ito Hospital, Japan.
Hideyuki ImaiDepartment of Internal Medicine, Ito Hospital, Japan.
Akiko SankodaDepartment of Internal Medicine, Ito Hospital, Japan.
Miho FukushitaDepartment of Internal Medicine, Ito Hospital, Japan.
Ai YoshiharaDepartment of Internal Medicine, Ito Hospital, Japan.
Masako MatsumotoDepartment of Internal Medicine, Ito Hospital, Japan.
Jaeduk Yoshimura NohDepartment of Internal Medicine, Ito Hospital, Japan.
Kiminori SuginoDepartment of Surgery, Ito Hospital, Japan.
Koichi ItoDepartment of Surgery, Ito Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 37-year-old, never-smoker, pregnant woman diagnosed with Graves' disease who had stable thyroid eye disease (TED) before pregnancy presented with aggravated proptosis and eyelid swelling at 13 weeks of pregnancy. Despite the administration of local triamcinolone and 3 cycles of corticosteroid pulse therapy from 25 to 28 weeks, the patient's visual acuity decline necessitated postpartum orbital decompression surgery. Although thyroid stimulating hormone (TSH) receptor antibody levels decreased during the mid- to late term of pregnancy, the TED worsened. This finding suggests that factors other than anti-TSH receptor antibodies may have a significant effect on disease severity.

Indexed as

Graves OphthalmopathyOptic Nerve DiseasesPregnancy ComplicationsAdultDecompression, SurgicalDisease ProgressionFemaleHumansPregnancydysthyroid optic neuropathyglucocorticoidsorbital decompressionpregnancythyroid eye disease

Identifiers

PMID39261069
PMCPMC12021514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.