Evidence map›Paper›PMID 39261067›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Tiopronin-induced Membranous Nephropathy Presenting with IgG4-predominant Staining Pattern.

Jumpei Yamashita, Yosuke Hirakawa, Yusuke Sato, Hiroyuki Abe, Shin'ichi Akiyama, Shoichi Maruyama, Haruki Kume, Masaomi Nangaku

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jumpei YamashitaDivision of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Japan.
Yosuke HirakawaDivision of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Japan.
Yusuke SatoDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Japan.
Hiroyuki AbeDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Japan.
Shin'ichi AkiyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Japan.
Shoichi MaruyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Japan.
Haruki KumeDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Japan.
Masaomi NangakuDivision of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tiopronin is a key drug used to treat cystinuria. A 41-year-old Japanese woman with cystinuria presented with eyelid edema and weight gain after the administration of tiopronin. Her serum albumin was 1.8 g/dL and her urinary protein level was 5.5 g/gCre. After cessation of tiopronin, she achieved remission of nephrotic syndrome (NS). Secondary NS due to tiopronin was evident based on the clinical course and laboratory values. A kidney biopsy showed membranous nephropathy (MN), and an immunofluorescence analysis revealed strong deposition of immunoglobulin G4 (IgG4). However, a previous case report of tiopronin-induced MN showed staining for IgG1 and IgG3. This case report suggests a novel etiology for tiopronin-induced MN.

Indexed as

Glomerulonephritis, MembranousImmunoglobulin GTioproninAdultFemaleHumansNephrotic SyndromeImmunoglobulin GTioproninmembranous nephropathynephrotic syndrometiopronin

Identifiers

PMID39261067
PMCPMC12021497

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.