Evidence map›Paper›PMID 39261064›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Patient with Atezolizumab-induced Encephalitis in Hepatocellular Carcinoma.

Kakeru Otomo, Masashi Fujita, Ryoji Sekine, Hidenori Sato, Naoto Abe, Tatsuro Sugaya, Chiharu Watanabe, Yosuke Takahata, Manabu Hayashi, Kazumichi Abe and 2 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Managing paraneoplastic GABABMC neurology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kakeru OtomoDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Masashi FujitaDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Ryoji SekineDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Hidenori SatoDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Naoto AbeDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Tatsuro SugayaDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Chiharu WatanabeDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Yosuke TakahataDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Manabu HayashiDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Kazumichi AbeDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Atsushi TakahashiDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Hiromasa OhiraDepartment of Gastroenterology, Fukushima Medical University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 65-year-old man treated with atezolizumab plus bevacizumab for hepatocellular carcinoma was admitted to our hospital with a fever, difficulty in moving, and aphasia. The patient became comatose immediately after admission. Imaging and cerebral fluid tests revealed no evidence of malignancy or infection. A diagnosis of atezolizumab-induced encephalitis was made, and steroid pulse therapy was initiated on admission, immediately after which the patient regained consciousness and was able to talk and walk. He was discharged with slight paralysis of his legs and was able to resume chemotherapy. An early diagnosis and treatment are required to improve the prognosis of encephalitis.

Indexed as

Antibodies, Monoclonal, HumanizedCarcinoma, HepatocellularEncephalitisLiver NeoplasmsAgedBevacizumabHumansMaleAntibodies, Monoclonal, HumanizedatezolizumabBevacizumabatezolizumabencephalitishepatocellular carcinomaimmune checkpoint inhibitorsimmune-related adverse events

Identifiers

PMID39261064
PMCPMC12097814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.