Evidence map›Paper›PMID 39260445›Full record

ArticleJournal of medicinal chemistry2024

Antibacterial and Anti-Inflammatory Activity of Branched Peptides Derived from Natural Host Defense Sequences.

Giada Meogrossi, Eva Tollapi, Alessandro Rencinai, Jlenia Brunetti, Silvia Scali, Eugenio Paccagnini, Mariangela Gentile, Pietro Lupetti, Simona Pollini, Gian Maria Rossolini and 4 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giada MeogrossiDepartment of Medical Biotechnology, University of Siena, 53100 Siena, Italy.
Eva TollapiDepartment of Medical Biotechnology, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-6144-1078
Alessandro RencinaiDepartment of Medical Biotechnology, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-3278-2778
Jlenia BrunettiDepartment of Medical Biotechnology, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-8144-7186
Silvia ScaliDepartment of Medical Biotechnology, University of Siena, 53100 Siena, Italy.
Eugenio PaccagniniDepartment of Life Sciences, University of Siena, 53100 Siena, Italy.
Mariangela GentileDepartment of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-4928-4652
Pietro LupettiDepartment of Life Sciences, University of Siena, 53100 Siena, Italy.
Simona PolliniDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Gian Maria RossoliniDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Andrea BerniniDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-7528-2749
Alessandro PiniDepartment of Medical Biotechnology, University of Siena, 53100 Siena, Italy.
Luisa BracciDepartment of Medical Biotechnology, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-0738-5746
Chiara FalcianiDepartment of Medical Biotechnology, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-1027-8482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance is a major global health threat, necessitating the development of new treatments and diverse molecules to combat severe infections and preserve the efficacy of existing drugs. Antimicrobial peptides (AMPs) offer a versatile arsenal against bacteria, and peptide structure branching can enhance their resistance to proteases and improve their overall efficacy. A small library of peptides derived from natural host defense peptides and synthesized in a tetrabranched form was selected against

Indexed as

Anti-Bacterial AgentsAnti-Inflammatory AgentsEscherichia coliMicrobial Sensitivity TestsAnimalsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBiofilmsHumansMiceAnti-Bacterial AgentsAnti-Inflammatory AgentsAntimicrobial Cationic PeptidesAntimicrobial Peptides

Identifiers

PMID39260445
PMCPMC11440494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.