ArticleScience advances2024
Modeling Lewy body disease with
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In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Understanding the genetic imperfections of Lewy body dementia.Molecular neurodegeneration · 2026Review
- Polymeric lysosome-targeting chimeras for extracellular α-synuclein degradation in Parkinson's disease.Acta neuropathologica communications · 2026Review
- TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation.Nature communications · 2026Article
- Potential common pathogenesis of several neurodegenerative diseases.Neural regeneration research · 2026Article
- α-Synuclein in Lewy Body Diseases: Progress, Remaining Challenges and Future Perspectives.Expert reviews in molecular medicine · 2026Review
- Spatially resolved molecular signatures of Lewy body dementia.Acta neuropathologica · 2026Article
- Human dorsal forebrain organoids show differentiation-state-specific protein secretion.iScience · 2025Article
- Alpha-synuclein seeding amplification assays in Lewy body dementia: a brief review.Molecular neurodegeneration · 2025Review
- LRRK2-mediated mitochondrial dysfunction in Parkinson's disease.The Biochemical journal · 2025Review
- Research models to study lewy body dementia.Molecular neurodegeneration · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Yunjung JinDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-7701-2371
Fuyao LiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3986-2412
Zonghua LiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-5242-9608
Tadafumi C IkezuDepartment of Clinical Trials and Biostatistics, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3511-6009
Justin O'LearyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-7538-8455
Manikandan SelvarajDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yiyang ZhuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-0272-1915
Yuka A MartensDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-5194-4269
Shunsuke KogaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-8868-9700
Hannah SanthakumarDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0008-4851-4437
Yonghe LiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-3489-6362
Wenyan LuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yang YouDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-0574-7827
Kiara LoloDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0008-7939-8977
Michael DeTureDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-4363-1262
Alexandra I BeasleyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-0153-1917
Mary D DavisDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-2123-4688
Pamela J McLeanDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-4870-5715
Owen A RossDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-4813-756X
Takahisa KanekiyoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-6751-9374
Tsuneya IkezuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3979-8596
Thomas CaulfieldDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-1055-3069
Jonathan CarrTygerberg Hospital and University of Stellenbosch, Tygerberg 7505, South Africa.ORCID 0000-0002-7677-426X
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-5487-1053
Guojun BuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-3491-1016
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7189-7917
Na ZhaoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-8648-9422
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI John Kornak · 2019 to 2026
$120.9MProject 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Na Zhao · 2021 to 2026
$42.0MUtilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM, MCLEAN, PAMELA J · 2019 to 2023
$14.5MApoE isoform-specific therapy for Alzheimer diseaseRF1AG046205 · NIA · MAYO CLINIC JACKSONVILLE · PI ZHAO, NA · 2019 to 2019
$3.1MElucidating the Pathomechanisms of APOE4 in Lewy Body DementiaR01AG087165 · NIA · MAYO CLINIC JACKSONVILLE · PI Owen A Ross, Na Zhao · 2024 to 2026
$2.3MNIA NIH HHS R01 AG087165NIA NIH HHS RF1 AG046205NIA NIH HHS U19 AG063911NIA NIH HHS U19 AG069701NINDS NIH HHS U54 NS110435
Abstract
Aggregated α-synuclein (α-SYN) proteins, encoded by the
Indexed as
alpha-SynucleinInduced Pluripotent Stem CellsLewy Body DiseaseOrganoidsCerebral CortexDrug Evaluation, PreclinicalHumansMitochondriaNeuronsalpha-SynucleinSNCA protein, human
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.