Evidence map›Paper›PMID 39259486›Full record

ArticleGenes & genomics2024

Association between TGF-β/BMP signaling pathway polymorphisms and the risk of primary ovarian insufficiency in Korean women.

Yong Hyun Ha, Ji Hyang Kim, Chang Soo Ryu, Ji Won Kim, Eun Ju Ko, Jeong Yong Lee, Ji Eun Shin, Young Ran Kim, Eun Hee Ahn, Nam Keun Kim

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Article in Genes & genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yong Hyun Ha *Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Ji Hyang Kim *Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Chang Soo RyuDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Ji Won KimDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, South Korea.
Eun Ju KoDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Jeong Yong LeeDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Ji Eun ShinDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Young Ran KimDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Eun Hee AhnDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea. bestob@chamc.co.kr.
Nam Keun KimDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea. nkkim@cha.ac.kr.ORCID 0000-0003-0541-3528

Funding

Korea Health Industry Development Institute HR22C1605National Research Foundation of Korea NRF-2022R1F1A1064169National Research Foundation of Korea NRF-2022R1F1A1074986National Research Foundation of Korea RS-2023-00246879
6 · The paper itself

Abstract

backgroundPrimary ovarian insufficiency (POI) is one of the leading female infertility diseases in which ovarian function stops before the age of 40. Reports that POI is associated with transforming growth factor (TGF)-β/bone morphogenetic protein (BMP) signaling pathway-associated genes (e.g., TGF-β, and BMP15) have been continuous since publication that the TGF-β superfamily acts as important regulators for ovary and placenta function in humans. Mechanistically, the secretion of follicle-stimulating hormone, progesterone, and estrogen is affected by the TGF-β superfamily in granulosa cells, which are involved in the development of theca cells, oocytes, and granulosa cells.

objectiveThis study aimed to identify the association between genes related to the TGF-β/BMP signaling pathway and the risk of POI pathogenesis.

methodsPossible associations between six gene polymorphisms and POI susceptibility were examined in 139 patients with POI and 345 control subjects.

resultsAllele combination of TGFBR1 rs334348 G > A and TGFBR3 rs1805110G > A exhibited association with decreased POI risk (adjusted odds ratio [AOR] = 0.165; 95% confidence interval [CI] 0.032-0.847; P = 0.031). Also, TGFBR1 rs1590 G > T and rs334348 G > A and TGFBR3 rs1805110 G > A allele combination exhibited association with decreased POI risk (OR = 0.553; 95% CI 0.374-0.816; P = 0.003).

conclusionThis study suggests that polymorphisms in the TGF-β signaling pathway genes can be useful biomarkers for POI diagnosis and treatment.

Indexed as

Polymorphism, Single NucleotidePrimary Ovarian InsufficiencyReceptor, Transforming Growth Factor-beta Type ISignal TransductionTransforming Growth Factor betaAdultBone Morphogenetic Protein 15Bone Morphogenetic ProteinsCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansProteoglycansReceptors, Transforming Growth Factor betaRepublic of KoreabetaglycanBMP15 protein, humanBone Morphogenetic Protein 15Bone Morphogenetic ProteinsProteoglycansReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type ITGFBR1 protein, humanTransforming Growth Factor betaBone morphogenetic proteinPolymorphismPrimary ovarian insufficiencyTransforming growth factor- β

Identifiers

PMID39259486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.