Evidence map›Paper›PMID 39259403›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2024

Diamond-like carbon (DLC) surface treatment decreases biofilm burden by S. aureus on titanium alloy in vitro- a pilot study.

Anabelle Visperas, Kaixi Cui, Md Masud Alam, Shonali Subramanian, Evan Butsch, Alison K Klika, Anna Cristina Samia, Nicolas S Piuzzi

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Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anabelle VisperasCleveland Clinic Adult Reconstruction Research (CCARR), Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Ave. A40, Cleveland, OH, 44113, USA.
Kaixi CuiDepartment of Chemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, USA.
Md Masud AlamDepartment of Chemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, USA.
Shonali SubramanianDepartment of Chemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, USA.
Evan ButschDepartment of Chemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, USA.
Alison K KlikaCleveland Clinic Adult Reconstruction Research (CCARR), Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Ave. A40, Cleveland, OH, 44113, USA.
Anna Cristina SamiaDepartment of Chemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, USA.
Nicolas S PiuzziCleveland Clinic Adult Reconstruction Research (CCARR), Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Ave. A40, Cleveland, OH, 44113, USA. piuzzin@ccf.org.ORCID http://orcid.org/0000-0003-3007-7538

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePeriprosthetic joint infection is a complication of total joint arthroplasty with treatment costs over $1.6 billion dollars per year in the US with high failure rates. Therefore, generation of coatings that can prevent infection is paramount. Diamond-like carbon (DLC) is an ideal coating for implants as they are wear-resistant, corrosion-resistant, inert, and have a low friction coefficient. The purpose of this study was to test the efficacy of DLC surface treatment in prevention of biofilm on titanium discs infected with Staphylococcus aureus in vitro.

methodsTitanium alloy discs (n = 4 non-coated and n = 4 DLC-coated) were infected with 5 × 10

resultsCrystal violet analysis yielded differences in the appearance of biofilm on implant surface where DLC-coated had a clumpier appearance but no difference in biofilm quantification. Interestingly, this clumpy appearance did lead to differences in SEM biofilm coverage where significantly less biofilm coverage was found on DLC-coated discs (81.78% vs. 54.17%, p < 0.003).

conclusionDLC-coated titanium alloy implants may have preventative properties in S. aureus infection. Observing differences in biofilm coverage does warrant additional testing including CFU titration and biofilm kinetics with eventual use in an animal model of periprosthetic joint infection.

Indexed as

AlloysBiofilmsCoated Materials, BiocompatibleProsthesis-Related InfectionsStaphylococcus aureusTitaniumCarbonDiamondHumansMicroscopy, Electron, ScanningPilot ProjectsStaphylococcal InfectionsSurface PropertiesAlloysCarbonCoated Materials, BiocompatibleDiamondTitaniumBiofilmImplant coatingInfectionInfection prevention

Identifiers

PMID39259403
PMCPMC11519165

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.