ArticleAging clinical and experimental research2024
Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study.
Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Development and internal validation of an explainable machine learning model for predicting functional disability trajectories in hospitalized older patients with chronic low back pain.BMC geriatrics · 2026Article
- Insulin resistance indicators in aortic disease: A large cohort study.Clinical and translational medicine · 2026Article
- Frailty and Incident Low Back Pain in Middle-Aged and Older Adults: Longitudinal Evidence and Genetic Triangulation.Journal of pain research · 2026Article
- Association between frailty status and pain, balance, and quality of life in patients with lumbar spinal stenosis.Turkish journal of medical sciences · 2026Article
- Construction and validation of the prediction model for kinesiophobia in older adults with chronic low back pain.BMC geriatrics · 2025Article
- Geneticsbiologiesingle cell and expression analysis for erectile dysfunction and cervical cancer targets.Discover oncology · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundPrevious observational studies have revealed a potentially robust bidirectional relationship between frailty and low back pain (LBP). However, the precise causal relationship remains unclear.
methodsTo examine the potential causal association between frailty and LBP, we conducted bidirectional two-sample Mendelian randomization analysis (MR) study. Genetic data on frailty index (FI) and LBP were acquired from publicly available genome-wide association studies (GWAS). Various MR methodologies were utilized, such as inverse variance weighting (IVW), weighted median, and MR-Egger, to evaluate causality. Additionally, sensitivity analyses were conducted to evaluate the robustness of the findings.
resultsGenetically predicted higher FI (IVW, odds ratio [OR] = 1.66, 95% CI 1.17-2.36, p = 4.92E-03) was associated with a higher risk of LBP. As for the reverse direction, genetic liability to LBP showed consistent associations with a higher FI (IVW, OR = 1.13, 95% CI 1.07-1.19, p = 2.67E-05). The outcomes from various MR techniques and sensitivity analyses indicate the robustness of our findings.
conclusionOur research findings provide additional evidence bolstering the bidirectional causal relationship between frailty and LBP.
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