Evidence map›Paper›PMID 39259349›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2025

Preclinical monitoring of radiation-induced brain injury via GluCEST MRI and resting-state fMRI at 7 T: an exploratory study on MRI-guided OAR avoidance.

Guodong Li, Hao Li, Na Weng, Caiyun Liu, Xianglin Li, Qinglong Li, Li Bin, Kai Zhu, Danqi Huang, Jia Liu and 2 more

Abstract read
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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Guodong LiDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Hao LiDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Na WengDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Caiyun LiuDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Xianglin LiDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Qinglong LiDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Li BinDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Kai ZhuDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Danqi HuangDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Jia LiuDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China.
Yan LiuDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China. liuericyan@hotmail.com.
Xu WangDepartment of Nuclear Medicine, Binzhou Medical University Hospital, School of Medical Imaging, Binzhou Medical University, Shandong, China. wangxu1978@163.com.ORCID 0009-0003-0862-9014

Funding

the National Natural Science Foundation of China 11805247the National Natural Science Foundation of China 81771828
6 · The paper itself

Abstract

purposeTo assess the value of glutamate chemical exchange saturation transfer (GluCEST) after whole-brain radiotherapy (WBRT) as an imaging marker of radiation-induced brain injury (RBI) and to preliminarily show the feasibility of multiparametric MRI-guided organ at risk (OAR) avoidance.

methodsRats were divided into two groups: the control (CTRL) group (n = 9) and the RBI group (n = 9). The rats in the RBI group were irradiated with an X‑ray radiator and then subjected to a water maze experiment 4 weeks later. In combination with high-performance liquid chromatography (HPLC), we evaluated the value of GluCEST applied to glutamate changes for RBI and investigated the effect of such changes on glutamatergic neuronal function.

resultsThe average GluCEST values were markedly lower in the hippocampus and cerebral cortex. Positive correlations were observed between GluCEST values and regional homogeneity (ReHo) values in both the hippocampus and the cerebral cortex. HPLC showed a positive correlation with GluCEST values in the hippocampus. GluCEST values were positively correlated with spatial memory.

conclusionGluCEST MRI provides a visual assessment of glutamate changes in RBI rats for monitoring OAR cognitive toxicity reactions and may be used as a biomarker of OAR avoidance as well as metabolism to facilitate monitoring and intervention in radiation damage that occurs after radiotherapy.

Indexed as

BrainCranial IrradiationGlutamic AcidMagnetic Resonance ImagingRadiation InjuriesRadiation Injuries, ExperimentalAnimalsCerebral CortexFeasibility StudiesHippocampusMaleMaze LearningRatsGlutamic AcidChemical exchange saturation transferCognitive impairmentMRI-guided radiotherapyRadiation brain injuryResting-state functional magnetic resonance imaging

Identifiers

PMID39259349

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.