Evidence map›Paper›PMID 39259314›Full record

ArticleMarine biotechnology (New York, N.Y.)2024

Chnoospora minima: a Robust Candidate for Hyperglycemia Management, Unveiling Potent Inhibitory Compounds and Their Therapeutic Potential.

Thilina Lakmini Gunathilaka, Upeka Bandaranayake, Mohamad Boudjelal, Rizwan Ali, Rajitha M Silva, Kalpa W Samarakoon, Pathmasiri Ranasinghe, L Dinithi C Peiris

Abstract read
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In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thilina Lakmini GunathilakaDepartment of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda, 10250, Sri Lanka. thilina@dss.cmb.ac.lk.
Upeka BandaranayakeGenetics & Molecular Biology Unit (Center for Biotechnology), Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda, 10250, Sri Lanka.
Mohamad BoudjelalKing Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, 11481, Saudi Arabia.
Rizwan AliKing Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, 11481, Saudi Arabia.
Rajitha M SilvaDepartment of Statistics, Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda, 10250, Sri Lanka.
Kalpa W SamarakoonInstitute for Combinatorial Advanced Research and Education (KDU-CARE), General Sir John Kotelawala Defence University, Ratmalana, 10390, Sri Lanka.
Pathmasiri RanasingheIndustrial Technology Institute, Halbarawa Gardens, Malabe, 10115, Sri Lanka.
L Dinithi C PeirisGenetics & Molecular Biology Unit (Center for Biotechnology), Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda, 10250, Sri Lanka. dinithi@sci.sjp.ac.lk.

Funding

University of Sri Jayewardenepura ASP/01/RE/SCI/2017/50
6 · The paper itself

Abstract

The present study aimed to isolate a bioactive compound from Sri Lankan edible marine brown algae, Chnoospora minima, to manage diabetes. The de-polysaccharide crude methanolic extract was partitioned using hexane, chloroform, and ethyl acetate with increased polarity. The samples were subjected to determine the quantitative phytochemical analysis, antioxidants, and antidiabetic potentials. Further, the potent antidiabetic fraction was selected to isolate an active compound using bioactivity-guided fractionation. From the selected extract, the chloroform fraction exhibited comparatively high TPC (59.01 ± 1.86 mg GAE/g), TFC (5.14 ± 0.43 mg QE/g) and alkaloid content (2.79 ± 0.31 PE/g of extract). Crude methanol extract exhibited a potent DPPH activity (IC

Indexed as

AntioxidantsHyperglycemiaHypoglycemic AgentsPhaeophyceaealpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsMolecular Docking SimulationSri Lankaalpha-Amylasesalpha-GlucosidasesAntioxidantsGlycoside Hydrolase InhibitorsHypoglycemic AgentsAntidiabeticAntioxidantBioactivityCarotenoidC. minimaFucoxanthin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.