Evidence map›Paper›PMID 39259188›Full record

ArticleThe ISME journal2024

Protist predation promotes antimicrobial resistance spread through antagonistic microbiome interactions.

Chen Liu, Yijin Wang, Zeyuan Zhou, Shimei Wang, Zhong Wei, Mohammadhossein Ravanbakhsh, Qirong Shen, Wu Xiong, George A Kowalchuk, Alexandre Jousset

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ISME journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chen LiuJiangsu Provincial Key Laboratory for Solid Organic Waste Utilization, Key Laboratory of Organic-Based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, No. 1 Weigang, Xuanwu district, Nanjing 210095, People's Republic of China.
Yijin WangJiangsu Provincial Key Laboratory for Solid Organic Waste Utilization, Key Laboratory of Organic-Based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, No. 1 Weigang, Xuanwu district, Nanjing 210095, People's Republic of China.
Zeyuan ZhouJiangsu Provincial Key Laboratory for Solid Organic Waste Utilization, Key Laboratory of Organic-Based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, No. 1 Weigang, Xuanwu district, Nanjing 210095, People's Republic of China.
Shimei WangJiangsu Provincial Key Laboratory for Solid Organic Waste Utilization, Key Laboratory of Organic-Based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, No. 1 Weigang, Xuanwu district, Nanjing 210095, People's Republic of China.
Zhong WeiJiangsu Provincial Key Laboratory for Solid Organic Waste Utilization, Key Laboratory of Organic-Based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, No. 1 Weigang, Xuanwu district, Nanjing 210095, People's Republic of China.
Mohammadhossein RavanbakhshEcology and Biodiversity Group, Department of Biology, Institute of Environmental Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Qirong ShenJiangsu Provincial Key Laboratory for Solid Organic Waste Utilization, Key Laboratory of Organic-Based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, No. 1 Weigang, Xuanwu district, Nanjing 210095, People's Republic of China.
Wu XiongJiangsu Provincial Key Laboratory for Solid Organic Waste Utilization, Key Laboratory of Organic-Based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, No. 1 Weigang, Xuanwu district, Nanjing 210095, People's Republic of China.
George A KowalchukEcology and Biodiversity Group, Department of Biology, Institute of Environmental Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Alexandre JoussetJiangsu Provincial Key Laboratory for Solid Organic Waste Utilization, Key Laboratory of Organic-Based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, No. 1 Weigang, Xuanwu district, Nanjing 210095, People's Republic of China.

Funding

Fundamental Research Funds for the Central Universities YDZX2023023National Key Research and Development Program of China 2023YFD1901402National Natural Science Foundation of China 42090064
6 · The paper itself

Abstract

Antibiotic resistance has grown into a major public health threat. In this study, we reveal predation by protists as an overlooked driver of antibiotic resistance dissemination in the soil microbiome. While previous studies have primarily focused on the distribution of antibiotic resistance genes, our work sheds light on the pivotal role of soil protists in shaping antibiotic resistance dynamics. Using a combination of metagenomics and controlled experiments in this study, we demonstrate that protists cause an increase in antibiotic resistance. We mechanistically link this increase to a fostering of antimicrobial activity in the microbiome. Protist predation gives a competitive edge to bacteria capable of producing antagonistic secondary metabolites, which secondary metabolites promote in turn antibiotic-resistant bacteria. This study provides insights into the complex interplay between protists and soil microbiomes in regulating antibiotic resistance dynamics. This study highlights the importance of top-down control on the spread of antibiotic resistance and directly connects it to cross-kingdom interactions within the microbiome. Managing protist communities may become an important tool to control outbreaks of antibiotic resistance in the environment.

Indexed as

BacteriaMicrobiotaSoil MicrobiologyAnti-Bacterial AgentsDrug Resistance, BacterialDrug Resistance, MicrobialEukaryotaMetagenomicsMicrobial InteractionsAnti-Bacterial Agentsantibiotic resistance genesmicrobial interactionsprotist predationsoil resistome

Identifiers

PMID39259188
PMCPMC11453101

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.