Evidence map›Paper›PMID 39258829›Full record

ArticleCancer cytopathology2025

Cytologic diagnosis of papillary renal neoplasm with reverse polarity.

Sarah J Wu, Andrew A Renshaw, Peter M Sadow, Navin R Mahadevan, Michelle S Hirsch, Murugesan Manoharan, Edmund S Cibas

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In one paragraph

Article in Cancer cytopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah J WuDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1755-6454
Andrew A RenshawDepartment of Pathology, Baptist Hospital and Miami Cancer Institute, Miami, Florida, USA.ORCID 0000-0002-1318-4238
Peter M SadowDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1036-6367
Navin R MahadevanDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Michelle S HirschDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Murugesan ManoharanDepartment of Surgery, Baptist Hospital and Miami Cancer Institute, Miami, Florida, USA.
Edmund S CibasDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1987-2004

Funding

Targeting the immunologic vulnerabilities of small cell lung carcinomaK08CA270077 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Navin Mahadevan · 2022 to 2026
$1.0M
Brigham and Women's Hospital Department of PathologyNCI NIH HHS K08 CA270077
6 · The paper itself

Abstract

backgroundPapillary renal neoplasm with reverse polarity is a recently recognized low-grade neoplasm with a favorable prognosis. To date, its cytologic features have not been well documented.

methodsTwo patients with papillary renal neoplasm with reverse polarity sampled by fine needle aspiration and core needle biopsy are described, one of whom is under active surveillance without clinical progression and the other is alive and well 16 years after partial nephrectomy.

resultsThe cytologic features included a mix of papillae and dispersed cells with abundant oncocytic cytoplasm and round, bland nuclei apically displaced away from the papillary core. Immunohistochemistry showed positive staining for GATA3 in both cases. Molecular studies on one of the cases showed a KRAS p.G12V mutation.

conclusionsThe cytologic features of this distinctive, indolent neoplasm are important to recognize because patients with papillary renal neoplasm with reverse polarity may be excellent candidates for partial nephrectomy or even active surveillance.

Indexed as

Kidney NeoplasmsAgedBiopsy, Fine-NeedleCarcinoma, PapillaryCarcinoma, Renal CellFemaleGATA3 Transcription FactorHumansMaleMiddle AgedMutationNephrectomyProto-Oncogene Proteins p21(ras)GATA3 protein, humanGATA3 Transcription FactorKRAS protein, humanProto-Oncogene Proteins p21(ras)cytologic featurespapillary renal neoplasm with reverse polarityPRNRP

Identifiers

PMID39258829
PMCPMC12258381

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