ArticleActa paediatrica (Oslo, Norway : 1992)2025
Depression of cortical neuronal activity after a low-dose fentanyl in preterm infants.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Electroencephalography during acute painful procedures in neonates: a scoping review.Pain reports · 2026Review
- Pain, Opioids, and Functional Connectivity in Preterm Infants.Children (Basel, Switzerland) · 2026Article
- Intranasal Fentanyl in Preterm Infants Undergoing Peripherally Inserted Central Catheter Placement (INFENT PICC): A Feasibility Randomized Controlled Trial.Children (Basel, Switzerland) · 2025Article
- Neonatal Electroencephalogram Recording with a Dry Electrode Cap: A Feasibility Study.Sensors (Basel, Switzerland) · 2025Article
- Depression of cortical neuronal activity after a low-dose fentanyl in preterm infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
aimOpioids might be harmful to the developing brain and dosing accuracy is important. We aimed at investigating fentanyl effects on cortical activity in infants using computational re-analysis of bedside recorded EEG signals.
methodsFifteen infants born at median 26.4 gestational weeks (range 23.3-34.1), with a birth weight 740 grams (530-1420) and postnatal age 7 days (5-11) received fentanyl 0.5 or 2 μg/kg intravenously before a skin-breaking procedure or tracheal intubation, respectively. Cortical activity was continuously recorded using amplitude-integrated electroencephalography (aEEG). Analyses using three computational EEG features representing cortical synchrony and signal power, were conducted five minutes pre- and 10 minutes post the drug administration.
resultsVisual assessment of trends displayed from the EEG metrics did not indicate systematic changes. However, the magnitude of the changes in the parietal and right hemisphere signals after the dose was significantly correlated (ρ < -0.5, p < 0.05) to the EEG amplitude and frequency power level before drug administration. This effect started after 3-4 min.
conclusionFentanyl, even in small doses, may affect cortical activity in the preterm brain. The effect is robustly related to the state of cortical activity prior to drug treatment, which must be taken into account when analysing the effects of sedative drugs.
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