Evidence map›Paper›PMID 39258766›Full record

SynthesisThe Australian & New Zealand journal of obstetrics & gynaecology2025

Pregnancy in women with mitochondrial disease-A literature review and suggested guidance for preconception and pregnancy care.

Lisa Hui, Pema Hayman, Ali Buckland, Michael C Fahey, David A Mackey, Andrew J Mallett, Daniel R Schweitzer, Clare P Stuart, Wai Yan Yau, John Christodoulou

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Australian & New Zealand journal of obstetrics & gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisa HuiDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-9720-3562
Pema HaymanCollege of Medicine and Dentistry, James Cook University, Cairns, Queensland, Australia.ORCID 0009-0005-2385-7837
Ali BucklandDepartment of Neurology, Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.
Michael C FaheyDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-0811-4785
David A MackeyCentre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0001-7914-4709
Andrew J MallettCollege of Medicine and Dentistry, James Cook University, Cairns, Queensland, Australia.ORCID 0000-0002-8752-2551
Daniel R SchweitzerDepartment of Neurology, Mater Hospital, Brisbane, Queensland, Australia.
Clare P StuartMito Foundation, Sydney, New South Wales, Australia.ORCID 0000-0002-1991-6495
Wai Yan YauDepartment of Neurology, Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.ORCID 0000-0001-6284-9163
John ChristodoulouBrain and Mitochondrial Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-8431-0641

Funding

Medical Research Future Fund 1196010Murdoch Children's Research InstituteQueensland Health Clinical Research FellowshipRoyal Children's Hospital FoundationThe Commonwealth of Australia MRF2023189University of Melbourne
6 · The paper itself

Abstract

Mitochondrial donation to reduce the risk of primary mitochondrial disease transmission from mother to child is now permitted under Australian law as part of a clinical trial. The energy demands of pregnancy have the potential to worsen mitochondrial disease symptoms and severity in affected women. We conducted a systematic literature review on mitochondrial disease in pregnancy; five cohort studies and 19 case reports were included. For many women with mitochondrial disease, pregnancy does not have a negative effect on health status. However, serious adverse outcomes may occur. We provide suggested guidelines for preconception counselling and antenatal care.

Indexed as

Mitochondrial DiseasesPreconception CarePregnancy ComplicationsPrenatal CareAustraliaFemaleHumansPractice Guidelines as TopicPregnancyassisted reproductive techniquesgeneticsmitochondrial diseasepregnancypregnancy complications

Identifiers

PMID39258766
PMCPMC11924174

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.