Evidence map›Paper›PMID 39258620›Full record

ArticleActa cirurgica brasileira2024

Preclinical evaluation of the functionality of a polymer-coated sirolimuseluting stent in pigs.

Sílvio César Perini, Jeanne Louise Fernandes Jesus, Alessandro Batista Soares, Rosane Angélica Ligabue, Luiz Carlos Bodanese

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sílvio César PeriniPontifícia Universidade Católica do Rio Grande do Sul - School of Medicine - Porto Alegre (RS) - Brazil.ORCID http://orcid.org/0000-0002-7171-2756
Jeanne Louise Fernandes JesusPontifícia Universidade Católica do Rio Grande do Sul - Polytechnic School - Porto Alegre (RS) - Brazil.ORCID http://orcid.org/0009-0007-7651-8112
Alessandro Batista SoaresPontifícia Universidade Católica do Rio Grande do Sul - School of Medicine - Porto Alegre (RS) - Brazil.ORCID http://orcid.org/0009-0007-4309-6785
Rosane Angélica LigabuePontifícia Universidade Católica do Rio Grande do Sul - Polytechnic School - Porto Alegre (RS) - Brazil.ORCID http://orcid.org/0000-0002-7086-8820
Luiz Carlos BodanesePontifícia Universidade Católica do Rio Grande do Sul - School of Medicine - Porto Alegre (RS) - Brazil.ORCID http://orcid.org/0000-0002-3142-7336

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the endothelial coverage of different stents in porcine carotid arteries. Research problem: How effective are polyurethane stents (PU) and PU + rapamycin (PU + RAPA) compared to bare-metal stents on endothelial coverage by neointima in pigs after 28 days?

methodsThe methodology had two phases for an interventional, experimental, prospective study, with three Moura pigs, 12 weeks old and weighing between 19 and 22.5 kg. In phase I, eight stents were implanted in carotid arteries; three stents coated with PU, three coated with PU + RAPA, and two without coating. After 28 days, phase II was carried out, consisting of euthanasia, removal of the stents, to evaluate the exposed area of the stent struts, and the percentage of endothelialization through optical microscopy and scanning electron microscopy.

resultsThe eight stents implanted with ultrasound sizing and post-dilation with a larger diameter balloon were analyzed by Doppler ultrasound, intravascular ultrasound, and angiography after 28 days.

conclusionsThis study showed complete endothelial coverage by the endoluminal neointima of the stent struts, good integration and coverage with the arterial wall, with no exposed struts showing the presence of intimal hyperplasia (whitish tissue).

Indexed as

Drug-Eluting StentsSirolimusAnimalsCarotid ArteriesCoated Materials, BiocompatibleEndothelium, VascularMicroscopy, Electron, ScanningModels, AnimalNeointimaPolymersPolyurethanesProspective StudiesReproducibility of ResultsSwineTime FactorsCoated Materials, BiocompatiblePolymersPolyurethanesSirolimus

Identifiers

PMID39258620
PMCPMC11384970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.