Evidence map›Paper›PMID 39258618›Full record

Trial reportActa cirurgica brasileira2024

Use of etomidate in endotracheal intubations in the emergency room during the COVID-19 pandemic: a randomized clinical trial.

Fernando Sabia Tallo, Marcelo Pires-Oliveira, Marianne Yumi Nakai, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Flávia de Sousa Gehrke, Murched Omar Taha, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues, Simone de Campos Vieira Abib

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Acta cirurgica brasileira, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Evidence-based Emergency Tracheal Intubation.American journal of respiratory and critical care medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fernando Sabia TalloUniversidade Federal de São Paulo - São Paulo (SP) - Brazil.ORCID http://orcid.org/0000-0003-3123-024X
Marcelo Pires-OliveiraCentro Universitário UNIME - Lauro de Freitas (BA) - Brazil.ORCID http://orcid.org/0000-0002-5839-1265
Marianne Yumi NakaiIrmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP) - Brazil.ORCID http://orcid.org/0000-0002-1945-1472
Lucas Antonio Duarte NicolauUniversidade Federal do Delta do Parnaíba - Parnaíba (PI) - Brazil.ORCID http://orcid.org/0000-0002-9904-2168
Jand Venes Rolim MedeirosUniversidade Federal do Delta do Parnaíba - Parnaíba (PI) - Brazil.ORCID http://orcid.org/0000-0002-7234-3382
Flávia de Sousa GehrkeCentro Universitário Faculdade de Medicina do ABC - Santo André (SP) - Brazil.ORCID http://orcid.org/0000-0002-2230-8853
Murched Omar TahaUniversidade Federal de São Paulo - São Paulo (SP) - Brazil.ORCID http://orcid.org/0000-0001-7323-1393
Afonso Caricati-NetoUniversidade Federal de São Paulo - São Paulo (SP) - Brazil.ORCID http://orcid.org/0000-0001-8615-4315
Francisco Sandro Menezes-RodriguesUniversidade Federal de São Paulo - São Paulo (SP) - Brazil.ORCID http://orcid.org/0000-0001-7913-0585
Simone de Campos Vieira AbibUniversidade Federal de São Paulo - São Paulo (SP) - Brazil.ORCID http://orcid.org/0000-0001-9675-0380

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeShock, cardiovascular problems, and respiratory failure constitute the main causes of death in patients cared in medical emergency rooms. Patients commonly require orotracheal intubation (OTI), a fact that has been intensified by diseases that generate important and fatal hemodynamic and respiratory problems in the affected patient.

methodsAlthough etomidate (ETO) is a highly used anesthetic for OTI, its use remains controversial in several scenarios. Some studies refer to an increase in mortality with its use in critically patients, while others do not refer to a difference. Therefore, we evaluated the mortality of patients submitted to OTI in the public hospital of a public federal university, with the use of ETO and other sedative-hypnotic drugs used in the induction of the performance of OTI, with the in-hospital mortality of patients cared in hospital.

resultsThe results demonstrate that the use of ETO as a hypnotic for OTI in the emergency room is not associated with a significant difference in morbidity or early mortality, within 30 days of hospitalization, compared with other hypnotics.

conclusionsThere was no difference in mortality between patients intubated in the emergency department who used ETO and those who used non-ETO hypnotic within 72 hours and 30 days.

Indexed as

COVID-19Emergency Service, HospitalEtomidateHospital MortalityHypnotics and SedativesIntubation, IntratrachealAdultAgedAnesthetics, IntravenousBrazilFemaleHumansMaleMiddle AgedPandemicsSARS-CoV-2Anesthetics, IntravenousEtomidateHypnotics and Sedatives

Identifiers

PMID39258618
PMCPMC11383194

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.