Evidence map›Paper›PMID 39258375›Full record

ArticleAnnals of surgery2026

Long-term Outcomes Following Colectomy and Liver Transplantation for Inflammatory Bowel Disease With Primary Sclerosing Cholangitis.

Abraham J Matar, Elissa Falconer, Michelle LaBella, Muneera R Kapadia, Carla F Justiniano, Kinga Skowron Olortegui, Randolph Steinhagen, Kurt Schultz, Anurag Pratap, Ira Leeds and 14 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Abraham J MatarDepartment of Surgery, Emory University, Atlanta, GA.ORCID 0000-0001-7351-7674
Elissa FalconerDepartment of Surgery, Emory University, Atlanta, GA.
Michelle LaBellaDepartment of Surgery, University of North Carolina, Chapel Hill, NC.
Muneera R KapadiaDepartment of Surgery, University of North Carolina, Chapel Hill, NC.
Carla F JustinianoDepartment of Surgery, University of Cincinnati, Cincinnati, OH.
Kinga Skowron OlorteguiDepartment of Surgery, University of Chicago, Chicago, IL.
Randolph SteinhagenDepartment of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY.
Kurt SchultzDepartment of Surgery, Yale University, New Haven, CT.
Anurag PratapDepartment of Surgery, Yale University, New Haven, CT.
Ira LeedsDepartment of Surgery, Yale University, New Haven, CT.
Lauren WeaverDepartment of Surgery, University of Minnesota, Minneapolis, MN.
Wolfgang GaertnerDepartment of Surgery, University of Minnesota, Minneapolis, MN.
Erik B FingerDepartment of Surgery, University of Minnesota, Minneapolis, MN.
Mary ThompsonDepartment of Surgery, University of Minnesota, Minneapolis, MN.
Lucas FairDepartment of Surgery, Baylor University Medical Center, Dallas, TX.
Alessandro FicheraDepartment of Surgery, Baylor University Medical Center, Dallas, TX.
Brendan P LovasikDepartment of Surgery, Washington University in St. Louis, St. Louis, MO.
William C ChapmanDepartment of Surgery, Washington University in St. Louis, St. Louis, MO.
Catherine L B McGeochDepartment of Surgery, Emory University, Atlanta, GA.
Mary Catherine CamachoDepartment of Surgery, Emory University, Atlanta, GA.
Marwan KazimiDepartment of Surgery, Emory University, Atlanta, GA.
Steven C KimDepartment of Surgery, Emory University, Atlanta, GA.
Virginia O ShafferDepartment of Surgery, Emory University, Atlanta, GA.
Jahnavi K SrinivasanDepartment of Surgery, Emory University, Atlanta, GA.

Funding

UNC Integrated Translational Oncology Program (UNC-iTOP)T32CA244125 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAM Y. KIM, Jen Jen Yeh · 2019 to 2026
$3.9M
NCI NIH HHS T32 CA244125
6 · The paper itself

Abstract

objectiveTo investigate the long-term outcomes of patients with combined primary sclerosing cholangitis/inflammatory bowel disease (PSC-IBD) undergoing both liver transplantation (LT) and total abdominal colectomy (TAC).

backgroundThe fraction of patients with PSC-IBD that require both LT and TAC is small, thereby limiting significant conclusions regarding long-term outcomes.

methodsAdult and pediatric patients from 9 centers from the U.S. IBD Surgery Collaborative who underwent staged LT and TAC for PSC-IBD were included. Long-term outcomes, including survival, were assessed.

resultsAmong 127 patients, 66 underwent TAC-before-LT, with a median time from TAC to LT of 7.9 years, whereas 61 underwent LT-before-TAC, with a median time from LT to TAC of 4.4 years. Median patient survival after TAC was significantly worse in those undergoing LT-before-TAC (16.0 vs 42.6 years, P = 0.007), whereas post-LT survival was not impacted by the order of TAC and LT (21.6 vs 22.0 years, P = 0.81). Patients undergoing TAC for medically refractory disease had a higher incidence of recurrent PSC ( P = 0.02) and biliary complications (0.09) compared with those undergoing TAC for oncologic indications. Definitive TAC reconstruction with either end ileostomy or ileal-pouch anal anastomosis did not impact post-LT or post-TAC outcomes.

conclusionsLong-term survival in PSC-IBD was contingent upon progression to LT and was not impacted by the need for TAC. Patients with PSC-IBD undergoing TAC for medically refractory disease had a higher incidence of recurrent PSC and biliary complications. The use of ileal-pouch anal anastomosis in PSC-IBD was a viable alternative to end ileostomy.

Indexed as

Cholangitis, SclerosingColectomyInflammatory Bowel DiseasesLiver TransplantationAdolescentAdultChildFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesSurvival RateTime FactorsTreatment Outcomecolectomyinflammatory bowel diseaseliver transplantationprimary sclerosing cholangitis

Identifiers

PMID39258375
PMCPMC12184207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.