Evidence map›Paper›PMID 39258166›Full record

ReviewInternational journal of particle therapy2024

Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report.

Reem Ahmad, Amelia Barcellini, Kilian Baumann, Malte Benje, Tamara Bender, Paloma Bragado, Alexandra Charalampopoulou, Reema Chowdhury, Anthony J Davis, Daniel K Ebner and 22 more

Abstract readReview
In one paragraph

Review in International journal of particle therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Effect of FLASH proton therapy on primary bronchial epithelial cell organoids.Clinical and translational radiation oncology · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Reem AhmadDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Amelia BarcelliniDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Kilian BaumannInstitute of Medical Physics and Radiation Protection, University of Applied Sciences Giessen, Giessen, Germany.
Malte BenjeBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Tamara BenderBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Paloma BragadoBiochemistry and Molecular Biology Department, Complutense University of Madrid, Madrid, Spain.
Alexandra CharalampopoulouUniversity School for Advanced Studies (IUSS), Pavia, Italy.
Reema ChowdhuryBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Anthony J DavisUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
Daniel K EbnerDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
John EleyDepartment of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Jake A KloeberDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Robert W MutterDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Thomas FriedrichBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Alvaro Gutierrez-UzquizaBiochemistry and Molecular Biology Department, Complutense University of Madrid, Madrid, Spain.
Alexander HelmBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Marta Ibáñez-MoraguesMedical Applications of Ionizing Radiation Unit, Technology Department, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Lorea IturriInstitut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, Orsay, France.
Jeannette JansenBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Miguel Ángel MorcilloMedical Applications of Ionizing Radiation Unit, Technology Department, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Daniel PuertaDepartamento de Física Atómica, Molecular y Nuclear, Universidad de Granada, Granada, Spain.
Anggraeini Puspitasari KokkoHollandPTC, Delft, the Netherlands.
Daniel Sánchez-ParcerisaGrupo de Física Nuclear, IPARCOS & IdISSC, Universidad Complutense de Madrid, Madrid, Spain.
Emanuele ScifoniTIFPA-INFN - Trento Institute for Fundamental Physics and Applications, Trento, Italy.
Takashi ShimokawaNational Institutes for Quantum Science and Technology (QST), Chiba, Japan.
Olga SokolBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Michael D StoryMayo Clinic, Jacksonville, Florida, USA.
Juliette ThariatCentre François Baclesse, Université de Caen Normandie, ENSICAEN, CNRS/IN2P3, LPC Caen UMR6534, Caen, France.
Walter TinganelliBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Francesco TommasinoTIFPA-INFN - Trento Institute for Fundamental Physics and Applications, Trento, Italy.
Charlot VandevoordeBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Cläre von NeubeckDepartment of Particle Therapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.

Funding

MSTP at Mayo Clinic RochesterT32GM145408 · NIGMS · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN, LISA A SCHIMMENTI · 2023 to 2026
$4.7M
Determining the optimal ion and fractionation scheme for the treatment of GBM in a comprehensive human organoid modelR01CA256848 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GROSSHANS, DAVID R · 2021 to 2025
$2.3M
Characterization of the cellular mechanisms of radiation induced brain necrosis for clinical interventionR01CA255596 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GROSSHANS, DAVID R · 2021 to 2025
$871k
NCI NIH HHS R01 CA255596NCI NIH HHS R01 CA256848NIGMS NIH HHS T32 GM145408
6 · The paper itself

Abstract

Particle therapy (PT) represents a significant advancement in cancer treatment, precisely targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth-dose profiles of the charged particles. Furthermore, their linear energy transfer and relative biological effectiveness enhance their capability to treat radioresistant tumors, including hypoxic ones. Over the years, extensive research has paved the way for PT's clinical application, and current efforts aim to refine its efficacy and precision, minimizing the toxicities. In this regard, radiobiology research is evolving toward integrating biotechnology to advance drug discovery and radiation therapy optimization. This shift from basic radiobiology to understanding the molecular mechanisms of PT aims to expand the therapeutic window through innovative dose delivery regimens and combined therapy approaches. This review, written by over 30 contributors from various countries, provides a comprehensive look at key research areas and new developments in PT radiobiology, emphasizing the innovations and techniques transforming the field, ranging from the radiobiology of new irradiation modalities to multimodal radiation therapy and modeling efforts. We highlight both advancements and knowledge gaps, with the aim of improving the understanding and application of PT in oncology.

Indexed as

Bragg peakParticle therapyRadiobiology

Identifiers

PMID39258166
PMCPMC11386331

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.