Evidence map›Paper›PMID 39257993›Full record

ArticleResearch square2024

SCN2A-linked myelination deficits and synaptic plasticity alterations drive auditory processing disorders in ASD.

Jun Hee Kim, Han-Gyu Bae, Wan-Chen Wu, Kaila Nip, Elizabeth Gould

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jun Hee KimUniversity of Michigan.ORCID 0000-0003-0207-8410
Wan-Chen WuUniversity of Michigan.
Kaila NipUT Health San Antonio.
Elizabeth GouldUT Health San Antonio.

Funding

Role of Adaptive Myelination in Auditory Brain PlasticityR01DC018797 · NIDCD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jun Hee Kim · 2021 to 2026
$2.9M
Role of SCN2A in Myelination and Neural Circuit Development in Autism Spectrum DisorderR01DC019371 · NIDCD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KIM, JUN HEE · 2021 to 2025
$2.6M
NIDCD NIH HHS R01 DC018797NIDCD NIH HHS R01 DC019371
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by complex sensory processing deficits. A key unresolved question is how alterations in neural connectivity and communication translate into the behavioral manifestations seen in ASD. Here, we investigate how oligodendrocyte dysfunction alters myelin plasticity and neuronal activity, leading to auditory processing disorder associated with ASD. We focus on the

Identifiers

PMID39257993
PMCPMC11384822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.