Evidence map›Paper›PMID 39257989›Full record

ArticleResearch square2024

Dynamic oxygen assessment techniques enable determination of anesthesia's impact on tissue.

Megan A Clark, Armin D Tavakkoli, Arthur F Petusseau, Augustino V Scorzo, Alireza Kheirollah, Scott C Davis, Rendall R Strawbridge, Petr Bruza, Brian W Pogue, David J Gladstone and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Megan A ClarkDartmouth College.
Armin D TavakkoliDartmouth College.
Arthur F PetusseauDartmouth College.
Augustino V ScorzoDartmouth College.
Alireza KheirollahDartmouth College.
Scott C DavisDartmouth College.
Rendall R StrawbridgeDartmouth College.
Petr BruzaDartmouth College.
Brian W PogueUniversity of Wisconsin-Madison.
David J GladstoneDartmouth College.
P Jack HoopesDartmouth College.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Brian William Pogue · 2001 to 2026
$27.9M
Optimization of MeV FLASH radiotherapy for normal tissue preservationU01CA260446 · NCI · DARTMOUTH COLLEGE · PI David J. Gladstone, Jack Hoopes · 2022 to 2026
$3.1M
Optical Analogs to MRI Contrast Agents for Surgical Guidance of Brain Tumor ResectionR01NS119504 · NINDS · DARTMOUTH COLLEGE · PI DAVIS, SCOTT C, ROBERTS, DAVID W · 2021 to 2025
$2.9M
Training in Surgical InnovationT32EB021966 · NIBIB · DARTMOUTH COLLEGE · PI Eric R Fossum, Sohail K Mirza · 2017 to 2026
$1.7M
NCI NIH HHS P01 CA084203NCI NIH HHS P30 CA023108NCI NIH HHS U01 CA260446NIBIB NIH HHS T32 EB021966NINDS NIH HHS R01 NS119504
6 · The paper itself

Abstract

Tissue oxygenation is well understood to impact radiosensitivity, with reports demonstrating a significant effect of breathing condition and anesthesia type on tissue oxygenation levels and radiobiological response. However, the temporal kinetics of intracellular and extracellular oxygenation have never been quantified, on the timescale that may affect radiotherapy studies. C57BL/6 mice were anesthetized using isoflurane at various percentages or ketamine/xylazine (ket/xyl: 100/10 mg/kg) (N = 48). Skin pO

Identifiers

PMID39257989
PMCPMC11384820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.