Evidence map›Paper›PMID 39257979›Full record

ArticleResearch square2024

Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice.

Ling Qin, Jiawei Lu, Qi He, Huan Wang, Lutian Yao, Michael Duffy, Hanli Guo, Corben Braun, Yuewei Lin, Yilu Zhou and 5 more

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Ling QinUNIVERSITY OF PENNSYLVANIA.ORCID 0000-0002-2582-0078
Jiawei LuUniversity of Pennsylvania.
Qi HeUniversity of Pennsylvania.
Huan WangUniversity of Pennsylvania.
Lutian YaoUniversity of Pennsylvania.
Michael DuffyUniversity of Pennsylvania.
Hanli GuoUniversity of Pennsylvania.
Corben BraunUniversity of Pennsylvania.
Yuewei LinUniversity of Pennsylvania.
Yilu ZhouUniversity of Pennsylvania.
Qiushi LiangUniversity of Pennsylvania.
Shovik BandyopadhyayUniversity of Pennsylvania.
Kai TanThe Children's Hospital of Philadelphia.
Yongwon ChoiUniversity of Pennsylvania Perelman School of Medicine.ORCID 0000-0002-1007-7998
Sherry LiuUniversity of Pennsylvania.

Funding

HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1M
Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Organ Specific Project - HeartU54HL165442 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MOFFITT, JEFFREY, PEI, LIMING · 2022 to 2025
$7.6M
Control of bone physiology by a novel type of adipose cellsR01AG069401 · NIA · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING · 2021 to 2025
$2.3M
NHLBI NIH HHS T32 HL007439NHLBI NIH HHS U54 HL165442NIA NIH HHS R01 AG069401
6 · The paper itself

Abstract

Bone resorption by osteoclasts is a critical step in bone remodeling, a process important for maintaining bone homeostasis and repairing injured bone. We previously identified a bone marrow mesenchymal subpopulation, marrow adipogenic lineage precursors (MALPs), and showed that its production of RANKL stimulates bone resorption in young mice using

Identifiers

PMID39257979
PMCPMC11384808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.