Evidence map›Paper›PMID 39257909›Full record

ArticleHealth science reports2024

An overview of sulbactam-durlobactam approval and implications in advancing therapeutics for hospital-acquired and ventilator-associated pneumonia by

Ayush Anand, Amogh Verma, Sarabjeet Kaur, Priyangi Kathayat, Rachel M Manoj, Aakanksha Aakanksha, Justice K Turzin, Prakasini Satapathy, Mahalaqua N Khatib, Shilpa Gaidhane and 4 more

Abstract read
In one paragraph

Article in Health science reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Turning the Tide Against Carbapenem-resistantOpen forum infectious diseases · 2025
    Article
  6. Review
  7. The global epidemiology of carbapenem-resistantJAC-antimicrobial resistance · 2025
    Review
  8. A National Surveillance of the Antibiotic Susceptibility ofAntibiotics (Basel, Switzerland) · 2025
    Article
  9. Successful Treatment of OXA-23Infection and drug resistance · 2025
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ayush AnandB. P. Koirala Institute of Health Sciences Dharan Nepal.ORCID 0000-0003-0279-4636
Amogh VermaRama Medical College Hospital and Research Centre Hapur India.
Sarabjeet KaurGlobal Consortium of Medical Education and Research Pune India.
Priyangi KathayatGlobal Consortium of Medical Education and Research Pune India.
Rachel M ManojGlobal Consortium of Medical Education and Research Pune India.
Aakanksha AakankshaGlobal Consortium of Medical Education and Research Pune India.
Justice K TurzinGlobal Consortium of Medical Education and Research Pune India.
Prakasini SatapathyCenter for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital Saveetha University Chennai India.
Mahalaqua N KhatibDivision of Evidence Synthesis, Datta Meghe Institute of Higher Education Global Consortium of Public Health and Research Wardha India.
Shilpa GaidhaneDatta Meghe Institute of Higher Education and Research Jawaharlal Nehru Medical College Wardha India.
Quazi S ZahiruddinDivision of Evidence Synthesis, Datta Meghe Institute of Higher Education South Asia Infant Feeding Research Network (SAIFRN), Global Consortium of Public Health and Research Wardha India.
Neelima KukretiSchool of Pharmacy Graphic Era Hill University Dehradun India.
Sarvesh RustagiSchool of Applied and Life Sciences Uttaranchal University Dehradun India.
Arihant SuranaDepartment of Internal Medicine St. Vincent Hospital Worcester Massachusetts USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Infections caused by Methods: PubMed, Web of Science, EMBASE, Clinical trials. gov, ICTRP, and CENTRAL were searched for studies on SUL-DUR for the treatment of hospital-acquired pneumonia and ventilator-associated pneumonia. Also, World Health Organization, U.S. Food and Drug Administration, and Centers for Disease Control and Prevention websites were searched for relevant information. Results: SUL-DUR, marketed as Xacduro, is a novel pharmaceutical combination that functions as a narrow-spectrum parenterally administered antibiotic. Sulbactam acts as a β-lactamase inhibitor, whereas durlobactam protects against degradation by Conclusion: The combination of sulbactam and durlobactam is a promising treatment option for HAP and VAP caused by ABC complex.

Indexed as

acinetobacterdurlobactamhospital acquired pneumoniasulbactamventilator associated pneumoniaXacduro

Identifiers

PMID39257909
PMCPMC11386240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.