Evidence map›Paper›PMID 39257885›Full record

ArticleFrontiers in medicine2024

Exploring HLA-C methylation patterns and nutritional status in Kichwa mothers and infants from Tena, Ecuador.

Erick Velastegui, Isaac B Falconí, Valeria I Garcia, Gabriela Munizaga, Carmen Matias de la Cruz, Yaritza Segura, Kerly Alcivar, Luz Valencia, Edwin Vera, Mindy S Muñoz and 3 more

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Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Erick Velastegui *Escuela Politécnica Nacional, Departamento de Ciencias de los Alimentos y Biotecnología, Facultad de Ingeniería Química y Agroindustria, Quito, Ecuador.
Isaac B Falconí *Escuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), ESPOL Polytechnic University, Guayaquil, Ecuador.
Valeria I GarciaEscuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), ESPOL Polytechnic University, Guayaquil, Ecuador.
Gabriela MunizagaEscuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), ESPOL Polytechnic University, Guayaquil, Ecuador.
Carmen Matias de la CruzEscuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), ESPOL Polytechnic University, Guayaquil, Ecuador.
Yaritza SeguraEscuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), ESPOL Polytechnic University, Guayaquil, Ecuador.
Kerly AlcivarEscuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), ESPOL Polytechnic University, Guayaquil, Ecuador.
Luz ValenciaEscuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), ESPOL Polytechnic University, Guayaquil, Ecuador.
Edwin VeraEscuela Politécnica Nacional, Departamento de Ciencias de los Alimentos y Biotecnología, Facultad de Ingeniería Química y Agroindustria, Quito, Ecuador.
Mindy S MuñozFacultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
Wim Vanden BergheEpigenetic Signaling Lab (PPES), Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Sarah LebeerDepartment of Bioscience Engineering, University of Antwerp, Antwerp, Belgium.
Andrea Orellana-ManzanoEscuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), ESPOL Polytechnic University, Guayaquil, Ecuador.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environment and lifestyle can affect the epigenome passed down from generation to generation. A mother's nutrition can impact the methylation levels of her offspring's epigenome, but it's unclear which genes may be affected by malnutrition during gestation or early development. In this study, we examined the levels of methylated GC in the promoter region of HLA-C in mothers and infants from the Kichwa community in Ecuador. To do this, we analyzed saliva samples using bisulfite DNA sequencing. While we did not observe any significant differences in the mean methylation percentages in exon 1 of HLA-C between mothers and their infants after the first two years of lactation and life, respectively, we did find that infants tended to increase their methylation level during the first two years of life, while mothers tended to decrease it after the first two years of breastfeeding. When we compared methylation levels between mothers and infants using an ANOVA/posthoc Tukey test, we found that the average methylation for the entire population was less than 3% at T1 and T2. Although there was a tendency for infants to have higher methylation levels during their first two years of life and for mothers to have lower methylation levels after the first two years of breastfeeding, the mean values were not significantly different. However, we found a significant difference when we contrasted the data using a Kruskal-Wallis test at 0.05 for T1 AND T2 (

Indexed as

epigeneticHLA-Cinheritancemethylationnutrition

Identifiers

PMID39257885
PMCPMC11385616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.