Evidence map›Paper›PMID 39257817›Full record

ArticlebioRxiv : the preprint server for biology2025

An alveolus lung-on-a-chip model of

Victoria Ektnitphong, Beatriz R S Dias, Priscila C Campos, Michael U Shiloh

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Victoria EktnitphongDepartment of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Y9.308, Dallas, TX 75390-9113.ORCID 0009-0007-1276-6563
Beatriz R S DiasDepartment of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Y9.308, Dallas, TX 75390-9113.ORCID 0000-0001-7433-3869
Priscila C CamposDepartment of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Y9.308, Dallas, TX 75390-9113.ORCID 0000-0003-1789-3290
Michael U ShilohDepartment of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Y9.308, Dallas, TX 75390-9113.ORCID 0000-0003-4329-2253

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7M
RP5: Chemical proteomic discovery of small-molecule probes for autophagy proteinsU19AI142784 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VIRGIN, HERBERT W · 2019 to 2023
$36.9M
Transmission Aerobiology of M. tuberculosis: Genes and Metabolic Pathways That Sustain Mtb Across an Evolutionary BottleneckP01AI159402 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BOUROUIBA, LYDIA · 2021 to 2025
$15.8M
Mechanisms of cough in Mycobacterium tuberculosis transmissionR01AI158688 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SHILOH, MICHAEL · 2021 to 2025
$3.6M
Interaction of Mycobacterium tuberculosis with upper airway mucosal cellsR01AI184584 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MICHAEL SHILOH · 2024 to 2026
$2.2M
Zeiss LSM 980 Airyscan 2 laser scanning confocal microscopeS10OD034383 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI ALTO, NEAL MATHEW · 2023 to 2023
$593k
NCI NIH HHS P30 CA142543NIAID NIH HHS P01 AI159402NIAID NIH HHS R01 AI158688NIAID NIH HHS R01 AI184584NIAID NIH HHS U19 AI142784NIH HHS S10 OD034383
6 · The paper itself

Abstract

Lung disease due to non-tuberculous mycobacteria (NTM) is rising in incidence. While both two dimensional cell culture and animal models exist for NTM infections, a major knowledge gap is the early responses of human alveolar and innate immune cells to NTM within the human alveolar microenvironment. Here we describe development of a humanized, three-dimensional, alveolus lung-on-a-chip (ALoC) model of

Identifiers

PMID39257817
PMCPMC11383683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.