Evidence map›Paper›PMID 39257816›Full record

ArticlebioRxiv : the preprint server for biology2024

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease.

Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen and 17 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Elena EubanksDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Katelyn VanderSleenDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Jiya ModyDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Neha PatelDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Benjamin SacksDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Mahsa Darestani FarahaniDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
Jinying WangDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
Jordan ElliottDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
Nora JaberDepartment of Cell Biology and Neuroscience & Institute for Quantitative Biomedicine, Rutgers University, Piscataway, NJ 08854, USA.
Fulya AkçimenMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Sara Bandres-CigaCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Fadel HelwehUNAM-National Nanotechnology Research Center and Institute of Materials Science & Nanotechnology, Bilkent University, Ankara, Turkey.
Jun LiuDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Sanjana ArchakamDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Robert KimelmanDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Bineet SharmaDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
Philip SochaDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Ananya GunturDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Tim BartelsUK Dementia Research Institute, University College London, London W1T 7NF, United Kingdom.
Ulf DettmerAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
M Maral MouradianDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.
Amir Houshang BahramiUNAM-National Nanotechnology Research Center and Institute of Materials Science & Nanotechnology, Bilkent University, Ankara, Turkey.
Wei DaiDepartment of Cell Biology and Neuroscience & Institute for Quantitative Biomedicine, Rutgers University, Piscataway, NJ 08854, USA.
Jean BaumDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
Zheng ShiDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
John HardyUK Dementia Research Institute, University College London, London W1T 7NF, United Kingdom.
Eleanna KaraDepartment of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ROBERT John LAUMBACH · 1988 to 2026
$47.4M
Understanding the viscoelasticity, surface tension, and membrane interactions of biomolecular condensates in live cellsR35GM147027 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Zheng Shi · 2022 to 2026
$1.6M
RNA Targeted Drug Discovery and Development for Parkinson DiseaseUH3NS116921 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI DISNEY, MATTHEW D, MOURADIAN, M. MARAL · 2021 to 2021
$851k
RNA Targeted Drug Discovery and Development for Parkinson DiseaseUG3NS116921 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI DISNEY, MATTHEW D, MOURADIAN, M. MARAL · 2020 to 2020
$523k
Beckman Coulter MoFlo Astrios EQ Cell SorterS10OD026876 · OD · RUTGERS, THE STATE UNIV OF N.J. · PI LASKIN, DEBRA L · 2019 to 2019
$504k
Micropipette-based quantification of neuronal protein condensates in live cellsR21DA056322 · NIDA · RUTGERS, THE STATE UNIV OF N.J. · PI SHI, ZHENG · 2022 to 2023
$392k
NIDA NIH HHS R21 DA056322NIEHS NIH HHS P30 ES005022NIGMS NIH HHS R35 GM147027NIH HHS S10 OD026876NINDS NIH HHS UG3 NS116921NINDS NIH HHS UH3 NS116921
6 · The paper itself

Abstract

Alpha-synuclein (αSyn) is an intrinsically disordered protein that accumulates in the brains of patients with Parkinson's disease and forms intraneuronal inclusions called Lewy Bodies. While the mechanism underlying the dysregulation of αSyn in Parkinson's disease is unclear, it is thought that prionoid cell-to-cell propagation of αSyn has an important role. Through a high throughput screen, we recently identified 38 genes whose knock down modulates αSyn propagation. Follow up experiments were undertaken for two of those genes,

Identifiers

PMID39257816
PMCPMC11384021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.