Evidence map›Paper›PMID 39257780›Full record

ArticlebioRxiv : the preprint server for biology2024

Extensive transmission and variation in a functional receptor for praziquantel resistance in endemic

Duncan J Berger, Sang-Kyu Park, Thomas Crellen, Tushabe John Vianney, Narcis B Kabatereine, James A Cotton, Richard Sanya, Alison Elliot, Edridah M Tukahebwa, Moses Adriko and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Duncan J BergerWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.
Sang-Kyu ParkDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Thomas CrellenWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.
Tushabe John VianneyDivision of Biomedical Engineering, University of Glasgow, G12 8LT Glasgow, UK.
Narcis B KabatereineVector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.
James A CottonWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.
Richard SanyaImmunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Alison ElliotImmunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Edridah M TukahebwaVector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.
Moses AdrikoVector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.
Claire J StandleyCenter for Global Health Science and Security, Georgetown University, 3900 Reservoir Rd NW, Washington DC 20007, USA.
Anouk GouvrasGlobal Schistosomiasis Alliance, Podium Space - Ealing Cross, 85 Uxbridge Road, London, W5 5BW, UK.
Safari Kinung'hiNational Institute for Medical Research (NIMR) Mwanza Centre, P.O Box 1462, Mwanza, United Republic of Tanzania.
Helmut HaashelminGuard, Süelfeld, Germany.
Muriel RaboneDepartment of Life Sciences, The Natural History Museum, London, SW7 5BD, UK; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, SW7 5BD, UK, London Centre for Neglected Tropical Disease Research (LCNTDR), London, UK.
Aidan EmeryDepartment of Life Sciences, The Natural History Museum, London, SW7 5BD, UK; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, SW7 5BD, UK, London Centre for Neglected Tropical Disease Research (LCNTDR), London, UK.
Poppy H L LambertonSchool of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Bonnie L WebsterDepartment of Life Sciences, The Natural History Museum, London, SW7 5BD, UK; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, SW7 5BD, UK, London Centre for Neglected Tropical Disease Research (LCNTDR), London, UK.
Fiona AllanDepartment of Life Sciences, The Natural History Museum, London, SW7 5BD, UK; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, SW7 5BD, UK, London Centre for Neglected Tropical Disease Research (LCNTDR), London, UK.
Sarah BuddenborgWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.
Matthew BerrimanWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.ORCID 0000-0002-9581-0377
Jonathan S MarchantDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.ORCID 0000-0001-6592-0877
Stephen R DoyleWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.ORCID 0000-0001-9167-7532
Joanne P WebsterDepartment of Pathology and Pathogen Biology, Royal Veterinary College, University of London, Herts, UK.

Funding

Resolving the properties of schistosome TRPMPZQ, the target of the anthelmintic drug praziquantelR01AI145871 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Wei Liu, JONATHAN S MARCHANT · 2020 to 2026
$3.1M
NIAID NIH HHS R01 AI145871Wellcome Trust
6 · The paper itself

Abstract

Mass-drug administration (MDA) of human populations using praziquantel monotherapy has become the primary strategy for controlling and potentially eliminating the major neglected tropical disease schistosomiasis. To understand how long-term MDA impacts schistosome populations, we analysed whole-genome sequence data of 570

Identifiers

PMID39257780
PMCPMC11383708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.