Evidence map›Paper›PMID 39257751›Full record

ArticlebioRxiv : the preprint server for biology2024

Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated

Soumitra Guin, Marhiah C Montoya, Xiaoyu Wang, Robert Zarnowski, David R Andes, Marvin J Meyers, Noelle S Williams, Damian J Krysan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Soumitra GuinDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri USA.
Marhiah C MontoyaDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA USA.
Xiaoyu WangDepartment of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA.
Robert ZarnowskiDepartment of Medicine, Section of Infectious Disease, University of Wisconsin, Madison, Wisconsin USA.ORCID 0000-0001-6343-1500
David R AndesDepartment of Medicine, Section of Infectious Disease, University of Wisconsin, Madison, Wisconsin USA.ORCID 0000-0002-7927-9950
Marvin J MeyersDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri USA.
Noelle S WilliamsDepartment of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin USA.
Damian J KrysanDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA USA.ORCID 0000-0001-6330-3365

Funding

Hit-to-lead optimization of broad spectrum antifungal phenothiazinesR21AI164578 · NIAID · UNIVERSITY OF IOWA · PI KRYSAN, DAMIAN J, MEYERS, MARVIN J · 2021 to 2022
$434k
NIAID NIH HHS R21 AI164578
6 · The paper itself

Abstract

Only three classes of antifungal drugs are currently in clinical use. Here, we report that derivatives of the malarial drug mefloquine have broad spectrum antifungal activity including difficult to treat molds and endemic fungi. Pharmacokinetic and efficacy studies of NSC-4377 indicate it penetrates the central nervous system and is active against

Identifiers

PMID39257751
PMCPMC11383691

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.