Evidence map›Paper›PMID 39257692›Full record

ArticleBiological psychiatry global open science2024

The Impacts of Adolescent Cannabinoid Exposure on Striatal Anxiety- and Depressive-Like Pathophysiology Are Prevented by the Antioxidant

Marta De Felice, Hanna J Szkudlarek, Taygun C Uzuneser, Mar Rodríguez-Ruiz, Mohammed H Sarikahya, Mathusha Pusparajah, Juan Pablo Galindo Lazo, Shawn N Whitehead, Ken K-C Yeung, Walter J Rushlow and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marta De FeliceAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Hanna J SzkudlarekAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Taygun C UzuneserAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Mar Rodríguez-RuizAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Mohammed H SarikahyaAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Mathusha PusparajahDepartment of Chemistry, Western University, London, Ontario, Canada.
Juan Pablo Galindo LazoDepartment of Chemistry, Western University, London, Ontario, Canada.
Shawn N WhiteheadDepartment of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Ken K-C YeungDepartment of Chemistry, Western University, London, Ontario, Canada.
Walter J RushlowAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Steven R LavioletteAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Exposure to Δ Methods: In the current study, we used an established preclinical adolescent rat model to examine the impacts of adolescent THC exposure on various behavioral, molecular, and neuronal biomarkers associated with increased mood and anxiety disorder vulnerability. Moreover, we investigated the protective properties of the antioxidant Results: We demonstrated that adolescent THC exposure induced long-lasting anxiety- and depressive-like phenotypes concomitant with differential neuronal and molecular abnormalities in the two subregions of the nucleus accumbens, the shell and the core. In addition, we report for the first time that Conclusions: The preventive effects of this antioxidant intervention highlight the critical role of redox mechanisms underlying cannabinoid-induced neurodevelopmental pathology and identify a potential intervention strategy for the prevention and/or reversal of these pathophysiological sequelae.

Indexed as

AccumbensAntioxidantAnxietyCannabinoidsDepressionNeurodevelopment

Identifiers

PMID39257692
PMCPMC11381987

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.