ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Disrupted Human-Dog Interbrain Neural Coupling in Autism-Associated Shank3 Mutant Dogs.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence of Physiological Comodulation During Human-Animal Interaction: A Systematic Review.Annals of the New York Academy of Sciences · 2026Pooled it
- Social attachment shapes interbrain synchrony.bioRxiv : the preprint server for biology · 2026Article
- Entangled Bonds: Dyadic Dependence and Co-Regulation in Western Urban Human-Dog Relationships.Animals : an open access journal from MDPI · 2026Review
- Bonded Green Exercise: A One Health Framework for Shared Nature-Based Physical Activity in the Human-Dog Dyad.Animals : an open access journal from MDPI · 2026Article
- A Conceptual Framework for the Co-Construction of Human-Dog Dyadic Relationship.Animals : an open access journal from MDPI · 2025Review
- Psychedelics and Pro-Social Behaviors: A Perspective on Autism Spectrum Disorders.ACS pharmacology & translational science · 2025Article
- A Study on the Attachment to Pets Among Owners of Cats and Dogs Using the Lexington Attachment to Pets Scale (LAPS) in the Basque Country.Animals : an open access journal from MDPI · 2025Article
- Behavior Coding of Adolescent and Therapy Dog Interactions During a Social Stress Task.Veterinary sciences · 2024Article
- Disrupted Human-Dog Interbrain Neural Coupling in Autism-Associated Shank3 Mutant Dogs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Dogs interact with humans effectively and intimately. However, the neural underpinnings for such interspecies social communication are not understood. It is known that interbrain activity coupling, i.e., the synchronization of neural activity between individuals, represents the neural basis of social interactions. Here, previously unknown cross-species interbrain activity coupling in interacting human-dog dyads is reported. By analyzing electroencephalography signals from both dogs and humans, it is found that mutual gaze and petting induce interbrain synchronization in the frontal and parietal regions of the human-dog dyads, respectively. The strength of the synchronization increases with growing familiarity of the human-dog dyad over five days, and the information flow analysis suggests that the human is the leader while the dog is the follower during human-dog interactions. Furthermore, dogs with Shank3 mutations, which represent a promising complementary animal model of autism spectrum disorders (ASD), show a loss of interbrain coupling and reduced attention during human-dog interactions. Such abnormalities are rescued by the psychedelic lysergic acid diethylamide (LSD). The results reveal previously unknown interbrain synchronizations within an interacting human-dog dyad which may underlie the interspecies communication, and suggest a potential of LSD for the amelioration of social impairment in patients with ASD.
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