Evidence map›Paper›PMID 39257287›Full record

SynthesisJournal of surgical oncology2024

Systemic chemotherapy in addition to CRS-HIPEC for colorectal peritoneal metastases: A critical systematic review on the impact on overall survival.

Teun B M van den Heuvel, Robin J Lurvink, Koen P B Rovers, Irene E G van Hellemond, Ignace H J T de Hingh

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Teun B M van den HeuvelDepartment of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
Robin J LurvinkDepartment of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
Koen P B RoversDepartment of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
Irene E G van HellemondDepartment of Medical Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
Ignace H J T de HinghDepartment of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-0642-7000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with resectable colorectal peritoneal metastases, it is unclear whether systemic chemotherapy, in addition to cytoreductive surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), improves overall survival (OS). This systematic review of 12 retrospective studies involving 3721 patients aimed to summarize the available evidence. Contradictory results were found regarding the effectiveness of neoadjuvant, adjuvant, and perioperative systemic therapies on OS, with a high risk of bias. Available evidence remains inconclusive, stressing the need for prospective, randomized trials, like the ongoing Dutch CAIRO6-trial.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsCytoreduction Surgical ProceduresHyperthermic Intraperitoneal ChemotherapyPeritoneal NeoplasmsChemotherapy, AdjuvantCombined Modality TherapyHumansNeoadjuvant TherapySurvival Ratecolorectal cancerCRS‐HIPECoverall survivalperitoneal metastasessystematic reviewsystemic chemotherapy

Identifiers

PMID39257287
PMCPMC11825997

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.