Evidence map›Paper›PMID 39256902›Full record

ArticleAddiction biology2024

Sex differences in neural networks recruited by frontloaded binge alcohol drinking.

Cherish E Ardinger, Yueyi Chen, Adam Kimbrough, Nicholas J Grahame, Christopher C Lapish

Abstract read
In one paragraph

Article in Addiction biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. GABAergic neurons in the ventrolateral periaqueductal gray mediate fentanyl withdrawal and self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Sexual Dimorphism in c-Fos Networks Governing Aggression.bioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Cherish E ArdingerAddiction Neuroscience, Department of Psychology and Indiana Alcohol Research Center, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID 0000-0003-4403-4600
Yueyi ChenDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.
Adam KimbroughDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0001-9434-4987
Nicholas J GrahameAddiction Neuroscience, Department of Psychology and Indiana Alcohol Research Center, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID 0000-0003-3279-2279
Christopher C LapishAddiction Neuroscience, Department of Psychology and Indiana Alcohol Research Center, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana, USA.

Funding

Translational Research and Science Education (OUT)P60AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Nicholas Joseph Grahame · 2003 to 2026
$45.5M
TRAINING GRANT ON GENETICS ASPECTS OF ALCOHOLISMT32AA007462 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CRISTINE L CZACHOWSKI · 1985 to 2026
$10.7M
RAT RESEARCH COMPONENTP50AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI LI, TING-KAI K · 1987 to 2002
$5.3M
Targeting computation in prefrontal cortex to improve decision-making and reduce compulsive drinking in rodent models.R01AA029409 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI CZACHOWSKI, CRISTINE L, LAPISH, CHRISTOPHER COURT · 2021 to 2025
$2.2M
Identifying the relationship between alcohol and Alzheimer's DiseaseR01AA029985 · NIAAA · PURDUE UNIVERSITY · PI Adam J Kimbrough · 2022 to 2026
$1.7M
Prefrontal cortex regulation of ethanol-reinforced behaviorR01AA023786 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LAPISH, CHRISTOPHER COURT · 2015 to 2019
$1.7M
Network wide analysis of brain activity involved in alcohol withdrawalR00AA027301 · NIAAA · PURDUE UNIVERSITY · PI KIMBROUGH, ADAM J · 2020 to 2022
$747k
Network wide analysis of brain activity involved in alcohol withdrawalK99AA027301 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KIMBROUGH, ADAM J · 2018 to 2019
$286k
Indiana Alcohol Research Center P60-AA007611NIAAA NIH HHS AA007462NIAAA NIH HHS AA023786NIAAA NIH HHS AA027301NIAAA NIH HHS AA029985NIAAA NIH HHS K99 AA027301NIAAA NIH HHS P50 AA007611NIAAA NIH HHS P60 AA007611NIAAA NIH HHS R00 AA027301NIAAA NIH HHS R01 AA023786NIAAA NIH HHS R01 AA029409NIAAA NIH HHS R01 AA029985NIAAA NIH HHS T32 AA007462
6 · The paper itself

Abstract

Frontloading is an alcohol drinking pattern where intake is skewed towards the onset of access. This study aimed to identify brain regions involved in frontloading. Whole brain imaging was performed in 63 C57Bl/6J (32 female, 31 male) mice that underwent 8 days of binge drinking using drinking-in-the-dark (DID). On Days 1-7 mice received 20% (v/v) alcohol or water for 2 h. Intake was measured in 1-min bins using volumetric sippers. On Day 8 mice were perfused 80 min into the DID session and brains were extracted. Brains were processed to stain for Fos protein using iDISCO+. Following light sheet imaging, ClearMap2.1 was used to register brains to the Allen Brain Atlas and detect Fos+ cells. For network analyses, Day 8 drinking patterns were used to characterize mice as frontloaders or non-frontloaders using a change-point analysis. Functional correlation matrices were calculated for each group from log

Indexed as

Binge DrinkingBrainMice, Inbred C57BLSex CharacteristicsAnimalsEthanolFemaleMaleMiceNerve NetSex FactorsEthanolbinge drinkingfrontloadingiDISCO+

Identifiers

PMID39256902
PMCPMC11387202

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.