Evidence map›Paper›PMID 39256891›Full record

ArticlePhysiological reports2024

PKM2 regulates metabolic flux and oxidative stress in the murine heart.

Katie C Y Lee, Allison L Williams, Lu Wang, Guoxiang Xie, Wei Jia, Anastasia Fujimoto, Mariana Gerschenson, Ralph V Shohet

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. ScalablebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Katie C Y LeeDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Allison L WilliamsDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Lu WangUniversity of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Guoxiang XieUniversity of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Wei JiaUniversity of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Anastasia FujimotoDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Mariana GerschensonDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Ralph V ShohetDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.ORCID 0000-0001-5966-6470

Funding

NM-INBRE Sequencing and Bioinformatics CoreP20GM103451 · NIGMS · NEW MEXICO STATE UNIVERSITY LAS CRUCES · PI Charlotte C. Gard · 2012 to 2026
$61.2M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Michael A. Ortega · 2017 to 2026
$21.5M
Pilot Project ProgramP30GM103341 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI SHOHET, RALPH V. · 2012 to 2016
$5.5M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
American Heart Association (AHA) 23PRE1027246NHLBI NIH HHS T32 HL115505NIGMS NIH HHS P20 GM103451NIGMS NIH HHS P20 GM113134NIGMS NIH HHS P30 GM103341
6 · The paper itself

Abstract

Cardiac metabolism ensures a continuous ATP supply, primarily using fatty acids in a healthy state and favoring glucose in pathological conditions. Pyruvate kinase muscle (PKM) controls the final step of glycolysis, with PKM1 being the main isoform in the heart. PKM2, elevated in various heart diseases, has been suggested to play a protective role in cardiac stress, but its function in basal cardiac metabolism remains unclear. We examined hearts from global PKM2 knockout (PKM2

Indexed as

Myocytes, CardiacOxidative StressAdenosine TriphosphateAnimalsCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2GlucoseMaleMiceMice, Inbred C57BLMice, KnockoutMitochondria, HeartMyocardiumPhospholambanPyruvate KinaseReactive Oxygen SpeciesAdenosine TriphosphateAtp2a2 protein, mouseCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2GlucosePhospholambanPkm protein, mousePyruvate KinaseReactive Oxygen SpeciesSarcoplasmic Reticulum Calcium-Transporting ATPasesglucoseglycolysismetabolismreactive oxygen species

Identifiers

PMID39256891
PMCPMC11387154

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.