Evidence map›Paper›PMID 39256856›Full record

ArticleStem cell research & therapy2024

Psychedelic LSD activates neurotrophic signal but fails to stimulate neural stem cells.

Xiaoxu Dong, He Lin, Yuting Li, Gang Pei, Shichao Huang

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoxu DongSchool of Life Science and Technology, Shanghai Tech University, Shanghai, China.
He LinThe Drug Reference Materials Laboratory, The Third Research Institute of Ministry of Public Security, Beijing, China.
Yuting LiDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Gang PeiState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Shichao HuangState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China. huangshichao@sibcb.ac.cn.ORCID 0000-0002-2287-2016

Funding

National Key Research and Development Program of China 2018YFA0108003National Science Foundation for Young Scientists of China 81901094
6 · The paper itself

Abstract

Accumulating evidence has shown that some hallucinogens, such as LSD, have fast and persistent effects on anxiety and depression. According to a proposed mechanism, LSD activates the TrkB and HTR2A signaling pathways, which enhance the density of neuronal dendritic spines and synaptic function, and thus promote brain function. Moreover, TrkB signaling is also known to be crucial for neural stem cell (NSC)-mediated neuroregeneration to repair dysfunctional neurons. However, the impact of LSD on neural stem cells remains to be elucidated. In this study, we observed that LSD and BDNF activated the TrkB pathway in human NSCs similarly to neurons. However, unlike BDNF, LSD did not promote NSC proliferation. These results suggest that LSD may activate an alternative mechanism to counteract the effects of BDNF-TrkB signaling on NSCs. Our findings shed light on the previously unrecognized cell type-specificity of LSD. This could be crucial for deepening our understanding of the mechanisms underlying the effects of LSD.

Indexed as

Brain-Derived Neurotrophic FactorHallucinogensLysergic Acid DiethylamideNeural Stem CellsReceptor, trkBSignal TransductionCell ProliferationCells, CulturedHumansMembrane GlycoproteinsNeuronsBDNF protein, humanBrain-Derived Neurotrophic FactorHallucinogensLysergic Acid DiethylamideMembrane GlycoproteinsReceptor, trkBtropomyosin-related kinase-B, humanBDNFLSDNeural stem cellTrkB signaling

Identifiers

PMID39256856
PMCPMC11389355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.