Evidence map›Paper›PMID 39256781›Full record

ArticleBMC medicine2024

Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.

Anat Yaskolka Meir, Guoying Wang, Xiumei Hong, Frank B Hu, Xiaobin Wang, Liming Liang

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03228875 (Early Life Origins of Pediatric and Adult Diseases), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03228875 recruitingnot on this map

Early Life Origins of Pediatric and Adult Diseases: Boston Birth Cohort Study

Typeobservational_patient_registrySponsorJohns Hopkins Bloomberg School of Public HealthRan1998 to 2028Enrolled24,000ConditionsMaternal Health, Child Health, Pregnancy Complications, Birth Outcome, Adverse
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Anat Yaskolka MeirDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Guoying WangCenter On Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Xiumei HongCenter On Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Frank B HuDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Xiaobin WangCenter On Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA. xwang82@jhu.edu.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. lliang@hsph.harvard.edu.

Funding

The Hopkins Population CenterP2CHD042854 · NICHD · JOHNS HOPKINS UNIVERSITY · PI Alison Gemmill · 2021 to 2026
$3.0M
NICHD NIH HHS P2C HD042854
6 · The paper itself

Abstract

backgroundGestational age (GEAA) estimated by newborn DNA methylation (GAmAge) is associated with maternal prenatal exposures and immediate birth outcomes. However, the association of GAmAge with long-term overweight or obesity (OWO) trajectories is yet to be determined.

methodsGAmAge was calculated for 831 children from a US predominantly urban, low-income, multi-ethnic birth cohort based on cord blood DNA methylation profile using Illumina EPIC array. Repeated anthropometric measurements aligned with pediatric primary care schedule allowed us to calculate body-mass-index percentiles (BMIPCT) at specific age and to define long-term weight trajectories from birth to 18 years.

resultsGAmAge was associated with BMIPCT trajectories, defined by 4 groups: stable (consistent OWO: "early OWO"; constant normal weight: "NW") or non-stable (OWO by year 1 of follow-up: "late OWO"; OWO by year 6 of follow-up: "NW to very late OWO"). GAmAge differentiated between the group with consistently normal BMIPCT pattern and the non-stable groups with late and very late OWO development. Such differentiation was observed in the age periods of birth to 1year, 3years, 6years, 10years, and 14years (p < 0.05 for all). The findings persisted after adjusting for GEAA, maternal smoking, delivery method, and child's sex in multivariate models. Birth weight was a mediator for the GAmAge effect on OWO status for specific groups at multiple age periods.

conclusionsGAmAge is associated with BMIPCT trajectories from birth to age 18 years, independent of GEAA and birth weight. If further confirmed, GAmAge may serve as an early biomarker for predicting BMI trajectory to inform early risk assessment and prevention of OWO.

trial registrationClinicalTrials.gov (NCT03228875).

Indexed as

Birth CohortDNA MethylationAdolescentBirth WeightBody Mass IndexBody-Weight TrajectoryBostonChildChild, PreschoolCohort StudiesFemaleGestational AgeHumansInfantInfant, NewbornMaleBMI percentilesEpigenetic clockOverweight or obesityPediatrics

Identifiers

PMID39256781
PMCPMC11389437

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.